Ferraresi A, Calabresi A, Castelli F, Vavassori A, Castelnuovo F, Scalzini A, Torti C, Quiros-Roldan E
Clinic of Infectious Diseases and Tropical Medicine, University of Brescia, Brescia, Italy.
Int J STD AIDS. 2012 Oct;23(10):753-5. doi: 10.1258/ijsa.2012.012042.
Lung cancer (LC) is the most common cancer among the non AIDS-defining malignancies in the highly active antiretroviral therapy (HAART) era. We described 23 HIV infected patients with a LC diagnosis followed in the Clinic of Tropical and Infectious Diseases of Brescia during the period of 1999-2009. All of these patients except two (n = 21, 91.3%) were cigarette smokers and all had at least one risk factor for developing cancer of the lung, or predisposing comorbidities, such as a COPD (chronic obstructive pulmonary disease) or a previous pneumonia. The median age at LC diagnosis was 53.6 years (range 21.2-71.4 years). Adenocarcinoma and squamous cell carcinoma were diagnosed in 10 cases (43.5%) respectively. In 21 subjects (91.3%) cancer was detected at stage IV with metastases. The median survival was 5.95 months. Greater intervention focused on the cessation of smoking is necessary, as well as the implementation of closer screening policies, especially in HIV-positive subjects with LC risk factors.
肺癌（LC）是高效抗逆转录病毒治疗（HAART）时代非艾滋病定义性恶性肿瘤中最常见的癌症。我们描述了1999年至2009年期间在布雷西亚热带和传染病诊所随访的23例确诊为肺癌的HIV感染患者。除两名患者外（n = 21，91.3%），所有这些患者均为吸烟者，且都至少有一个患肺癌的风险因素或易感合并症，如慢性阻塞性肺疾病（COPD）或既往肺炎。肺癌诊断时的中位年龄为53.6岁（范围21.2 - 71.4岁）。腺癌和鳞状细胞癌分别在10例（43.5%）中被诊断出。21例患者（91.3%）在IV期发现有转移。中位生存期为5.95个月。有必要加大戒烟干预力度，以及实施更密切的筛查政策，尤其是针对有肺癌风险因素的HIV阳性患者。
