噻嗪类药物化合物对白化大鼠睾丸蛋白质和胆固醇含量的影响。
Effect of thiazide drug compound on the testicular protein and cholesterol contents of albino rat.
作者信息
Yadav Hemlata, Singh P K
机构信息
Department of Zoology, School of Life Sciences, Khandari Campus, 282002 Agra.
出版信息
Indian J Clin Biochem. 2003 Jul;18(2):206-8. doi: 10.1007/BF02867388.
In this study the effect of thiazide diuretic compound on the protein and cholesterol contents in the testes of albino rats as the experimental model. The drug thiazide was administered orally daily for 10,20 and 30 days at the dose of 100mg/kg body weight. Total protein decrease in the testes of rats were evidenced may be due to the side effects of thiazide drug compound which is linked with the hyponatremia and protein metabolism. An elevated level of cholesterol contents observed in thiazide treated rats also revealed that the side effect of drug compound thiazide and also may be due to the stimulation of catecholamine which is stimulated therefore, the biochemical estimation such as protein and cholesterol in the testes after the thiazide treatment determined the effectiveness of diuretic drug compound would provide clinical evidences of their side effects.
在本研究中，以白化大鼠为实验模型，研究噻嗪类利尿化合物对其睾丸中蛋白质和胆固醇含量的影响。以100mg/kg体重的剂量，每天口服给予噻嗪类药物，持续10、20和30天。大鼠睾丸中总蛋白减少，这可能是由于噻嗪类药物化合物的副作用所致，该副作用与低钠血症和蛋白质代谢有关。在接受噻嗪治疗的大鼠中观察到胆固醇含量升高，这也揭示了噻嗪类药物化合物的副作用，也可能是由于儿茶酚胺的刺激所致。因此，噻嗪治疗后对睾丸中蛋白质和胆固醇等生化指标的测定，确定利尿药物化合物的有效性，将为其副作用提供临床证据。
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