1Department of Cardiology, Adana Numune Education and Research Hospital, Adana, Turkey.
Angiology. 2014 Jan;65(1):37-42. doi: 10.1177/0003319712463816. Epub 2012 Oct 29.
We assessed the relationship between contrast-induced nephropathy (CIN) and SYNTAX score (SS) and serum uric acid (SUA) levels in patients with ST elevation myocardial infarction (STEMI). A total of 835 STEMI patients in whom primary percutaneous coronary intervention was performed in our cardiology clinic were included in this study (615 male, 220 female; mean age 58.1 ± 12.2 years). The patients were divided into 2 groups (CIN and non-CIN). Contrast-induced nephropathy was observed in 9.6% (80) of patients; SS (13.9 ± 6.2/22.1 ± 5.8) and SUA (5.1 ± 0.9/6.2 ± 0.9) values in the CIN group were higher compared with the non-CIN group (P < .001, for all). All SS (95% confidence interval [CI] = 1.136-1.250, P = .001), SUA (95% CI = 1.877-3.236, P = .002), and diabetes (95% CI = 0.998-1.039, P = .026) were independent predictors of CIN in logistic regression analysis. Procedures that can prevent CIN may be beneficial in patients at high risk as identified by the SS and SUA levels.
我们评估了对比剂诱导肾病（CIN）与 ST 段抬高型心肌梗死（STEMI）患者 SYNTAX 评分（SS）和血清尿酸（SUA）水平之间的关系。本研究纳入了在我院心内科行直接经皮冠状动脉介入治疗的 835 例 STEMI 患者（男 615 例，女 220 例；平均年龄 58.1 ± 12.2 岁）。患者分为 2 组（CIN 组和非 CIN 组）。9.6%（80 例）的患者发生 CIN；CIN 组的 SS（13.9 ± 6.2/22.1 ± 5.8）和 SUA（5.1 ± 0.9/6.2 ± 0.9）值高于非 CIN 组（均 P <.001）。所有 SS（95%置信区间 [CI] = 1.136-1.250，P =.001）、SUA（95% CI = 1.877-3.236，P =.002）和糖尿病（95% CI = 0.998-1.039，P =.026）在 logistic 回归分析中均为 CIN 的独立预测因子。对于 SS 和 SUA 水平提示的高危患者，预防 CIN 的操作可能有益。
