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止血管理的未来。

The future of hemostasis management.

机构信息

Richardson Laboratory, Department of Pathology and Molecular Medicine, Queen's University, Kingston, Ontario, Canada.

出版信息

Pediatr Blood Cancer. 2013;60 Suppl 1:S44-7. doi: 10.1002/pbc.24334. Epub 2012 Oct 25.

Abstract

We are in the midst of an unprecedented period for the development of new therapeutic products to treat patients with bleeding diseases. While current hemostatic treatments are already very effective and safe, new agents to enhance convenience and further improve both short- and long-term efficacy of treatment are under development. Some of these products have already reached the clinic for early phase trials, and others will be available shortly. The strategies being evaluated for hemostatic enhancement range from gene and nucleic acid-based approaches, to the development of complex, naturally occurring molecules such as the non-anticoagulant polysaccharide, fucoidan. There is every likelihood that combinations of these treatment approaches will further improve the quality of bleeding disease management over the next 5 years and beyond.

摘要

我们正处于开发新型治疗产品以治疗出血性疾病患者的空前时期。虽然目前的止血治疗方法已经非常有效和安全,但为了提高便利性并进一步提高治疗的短期和长期效果,正在开发新的药物。其中一些产品已经进入早期临床试验阶段,其他产品也将很快上市。正在评估的止血增强策略包括基于基因和核酸的方法,以及开发复杂的天然存在的分子,如非抗凝多糖,褐藻聚糖。这些治疗方法的组合很有可能在未来 5 年内进一步提高出血性疾病管理的质量。

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