四线棘唇线虫感染和接种疫苗小鼠的血液学参数
Aspicularis tetraptera Induced Hematological Parameters in Infected and Vaccinated Mice.
作者信息
Gaherwal S, Solanki S, Prakash M M, Wast N
机构信息
Department of Biotechnology, Gov. Holkar Science College, Indore (M.P.), India.
出版信息
Iran J Parasitol. 2012;7(2):61-6.
BACKGROUND
The present study deals with the effect of helminthic infection as Nematode parasite like Aspiculuris tetraptera on the haematological parameters of infected and vaccinated mice.
METHODS
Totally 15 mice were used. Five mice were used for positive control, 5 mice used for negative control and 5 mice used for experiment. The hematological parameters were studied viz. RBC, Hb, and serum protein values.
RESULTS
The mice carrying heavy infection showed decrease in the Hb, RBC, and serum protein but in the vaccinated mice, all studied parameters were become on normal range. The level of immune response was assessed based on above studied hematological parameters in infected and vaccinated mice with Aspiculuris tetraptera.
CONCLUSION
The increased value of RBC, Hb and Serum protein in infected and vaccinated mice compared to infected and non vaccinated suggested the involvement of blood parameters in immune response. This study also proves that somatic antigen of A. tetraptera was effective in imparting immunity in mice.
背景
本研究探讨了诸如四翼无刺线虫等线虫寄生虫的蠕虫感染对感染及接种疫苗小鼠血液学参数的影响。
方法
共使用15只小鼠。5只小鼠用于阳性对照，5只小鼠用于阴性对照，5只小鼠用于实验。研究了血液学参数，即红细胞、血红蛋白和血清蛋白值。
结果
重度感染的小鼠血红蛋白、红细胞和血清蛋白降低，但接种疫苗的小鼠中，所有研究参数均在正常范围内。根据上述对感染及接种四翼无刺线虫疫苗小鼠的血液学参数研究评估免疫反应水平。
结论
与感染但未接种疫苗的小鼠相比，感染及接种疫苗小鼠的红细胞、血红蛋白和血清蛋白值升高，表明血液参数参与了免疫反应。本研究还证明四翼无刺线虫的体细胞抗原在赋予小鼠免疫力方面有效。
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