Scott M E
Institute of Parasitology, Macdonald College of McGill University, Ste-Anne de Bellevue, Quebec, Canada.
Parasitology. 1988 Aug;97 ( Pt 1):101-14. doi: 10.1017/s0031182000066786.
The purpose of this study was to determine whether predisposition to Heligmosomoides polygyrus and Aspiculuris tetraptera (Nematoda) exists within a naturally infected population of mice. A breeding mouse population was housed in a spacious arena in which endemic infections of H. polygyrus and A. tetraptera were present. H. polygyrus were over-dispersed in the mouse population. Prevalence reached 100% by the age of 3 weeks; intensity of infection increased to a peak in the 10 to 15-week-old mice, and remained high throughout life. A group of 73 mice was treated with pyrantel pamoate, and the expelled worms were counted. Mice were returned to the arena. Daily egg production was monitored 4, 8, 12 and 14 weeks after treatment. Mice were then killed and numbers of H. polygyrus and A. tetraptera were counted. Significant positive correlations were detected between numbers of H. polygyrus at first treatment and at necropsy, indicating the existence of predisposition. Similar results were obtained for A. tetraptera. Correlations improved when data were analysed by age class of mice. Analyses based on egg-count data during reinfection did not support the hypothesis of predisposition, however. A. tetraptera and H. polygyrus burdens were significantly correlated only in 3 to 4-week-old mice at the time of the treatment.
本研究的目的是确定在自然感染的小鼠群体中是否存在对多枝细颈线虫和四翼无刺线虫（线虫纲）的易感性。一个繁殖小鼠群体饲养在一个宽敞的场地中，该场地存在多枝细颈线虫和四翼无刺线虫的地方性感染。多枝细颈线虫在小鼠群体中分布不均。3周龄时患病率达到100%；感染强度在10至15周龄的小鼠中升至峰值，并在整个生命过程中保持较高水平。一组73只小鼠用噻嘧啶治疗，并对排出的蠕虫进行计数。小鼠被放回场地。在治疗后4、8、12和14周监测每日产蛋量。然后处死小鼠，对多枝细颈线虫和四翼无刺线虫的数量进行计数。在首次治疗时和尸检时多枝细颈线虫的数量之间检测到显著的正相关，表明存在易感性。四翼无刺线虫也得到了类似的结果。当按小鼠年龄组分析数据时，相关性有所改善。然而，基于再感染期间的虫卵计数数据分析不支持易感性假说。仅在治疗时3至4周龄的小鼠中，四翼无刺线虫和多枝细颈线虫的负荷显著相关。
