Gorodetskaya E A, Dugin S F, Golikov M A, Kapelko V I, Medvedev O S
Cardiology Research Center of the U.S.S.R., Academy of Medical Sciences, Moscow.
Can J Physiol Pharmacol. 1990 Feb;68(2):211-5. doi: 10.1139/y90-033.
Cardiac contractile function and hemodynamic parameters of control and adriamycin-treated (2 mg/kg once a week for 10 weeks) rats were studied both in the anesthetized (hexenal, 20 mg/kg) and conscious state. Radiolabelled microspheres (diameter, 15 microns) were used to measure systemic and regional hemodynamics. No significant differences between the control and adriamycin-treated groups in cardiac contractile function, total peripheral resistance, and regional blood flow (except muscles) was found in anesthetized animals. In the conscious state, a significantly higher (+70%) total peripheral resistance combined with lower blood flow in the skin and spleen was observed in adriamycin-treated rats. The response of the heart rate to changes in the arterial pressure induced by nitroglycerin and phenylephrine injection was greatly diminished after adriamycin treatment. Isoprenaline (0.64 micrograms.kg-1.min-1) increased left ventricular contractile indices approximately twofold and heart rate by 30% in the control group, while in adriamycin-treated rats only minor changes in these parameters were observed. However, cardiac output rose by 36% and total peripheral resistance fell by 36% in these animals. Results show that prolonged adriamycin treatment leads to decreased inotropic response to beta-adrenoceptor stimulation and reduced baroreflex control. These changes occur in the stage preceding congestive heart failure.
在麻醉（己烯醛，20mg/kg）和清醒状态下，研究了对照组和阿霉素治疗组（每周一次，2mg/kg，共10周）大鼠的心脏收缩功能和血流动力学参数。使用放射性标记的微球（直径15微米）测量全身和局部血流动力学。在麻醉动物中，对照组和阿霉素治疗组在心脏收缩功能、总外周阻力和局部血流（肌肉除外）方面未发现显著差异。在清醒状态下，阿霉素治疗的大鼠观察到总外周阻力显著升高（+70%），同时皮肤和脾脏的血流降低。阿霉素治疗后，硝酸甘油和去氧肾上腺素注射引起的动脉压变化对心率的反应大大减弱。在对照组中，异丙肾上腺素（0.64微克·千克-1·分钟-1）使左心室收缩指数增加约两倍，心率增加30%，而在阿霉素治疗的大鼠中，这些参数仅观察到微小变化。然而，这些动物的心输出量增加了36%，总外周阻力下降了36%。结果表明，长期阿霉素治疗导致对β-肾上腺素能受体刺激的变力反应降低和压力反射控制减弱。这些变化发生在充血性心力衰竭之前的阶段。
