Falconer J, Wada J A, Martin W, Li D
Division of Neurosciences, University of British Columbia, Vancouver, Canada.
Can J Neurol Sci. 1990 Feb;17(1):35-9. doi: 10.1017/s0317167100029991.
During the investigation of intractable epilepsy, neuronal migration anomalies [NMA] were discovered in three patients. The first patient had abnormally positioned gray matter within the walls of both lateral ventricles. The second patient had a post operative cystic area in the right parietal-occipital lobes and an area of NMA within the right temporal lobe. The third patient had abnormally thickened gray matter in the right operculum. Long term CCTV-EEG monitoring of these three patients revealed ictal discharges originating from the area of abnormal gray matter in patients 2 and 3. PET scanning showed the areas of NMA in all three patients to have similar metabolic activity to normal gray matter. These cases illustrate the value of various imaging modalities and suggest some interesting physiology of a spectrum of neuronal migration anomalies.
在难治性癫痫的调查过程中，三名患者被发现存在神经元迁移异常（NMA）。第一名患者双侧侧脑室壁内灰质位置异常。第二名患者右顶枕叶术后出现囊性区域，右颞叶存在NMA区域。第三名患者右盖部灰质异常增厚。对这三名患者进行的长期闭路电视脑电图监测显示，患者2和患者3的发作期放电起源于异常灰质区域。正电子发射断层扫描（PET）显示，所有三名患者的NMA区域与正常灰质具有相似的代谢活性。这些病例说明了各种成像方式的价值，并提示了一系列神经元迁移异常的一些有趣生理学现象。
