Institute for Molecular Bioscience, The University of Queensland, 306 Carmody Road, Brisbane, Queensland 4072, Australia.
ACS Chem Biol. 2013 Jan 18;8(1):105-15. doi: 10.1021/cb3005116. Epub 2012 Nov 9.
Aminoglycoside antibiotics were among the first antibiotics discovered and used clinically. Although they have never completely fallen out of favor, their importance has waned due to the emergence of other broad-spectrum antibiotics with fewer side effects. Today, with the dramatically increasing rate of infections caused by multidrug-resistant bacteria, focus has returned to aminoglycoside antibiotics as one of the few remaining treatment options, particularly for Gram-negative pathogens. Although the mechanisms of resistance are reasonably well understood, our knowledge about the mode of action of aminoglycosides is still far from comprehensive. In the face of emerging bacterial infections that are virtually untreatable, it is time to have a fresh look at this old class to reinvigorate the struggle against multidrug-resistant pathogens.
氨基糖苷类抗生素是最早发现和临床应用的抗生素之一。尽管它们从未完全失宠，但由于出现了其他副作用较少的广谱抗生素，它们的重要性已经降低。如今，由于耐多药细菌引起的感染率急剧上升，人们再次将氨基糖苷类抗生素作为为数不多的治疗选择之一，特别是针对革兰氏阴性病原体。尽管耐药机制已经得到了很好的理解，但我们对氨基糖苷类抗生素作用模式的了解仍然远远不够。面对几乎无法治疗的新出现的细菌感染，现在是时候重新审视这一古老的类别，为对抗耐多药病原体注入新的活力。
