Research Core for Interdisciplinary Sciences, Okayama University, Kita-ku, Okayama, Japan.
Mol Ecol. 2013 Mar;22(5):1356-65. doi: 10.1111/mec.12091. Epub 2012 Oct 30.
Cryptic genetic variation (CGV) or a standing genetic variation that is not ordinarily expressed as a phenotype is released when the robustness of organisms is impaired under environmental or genetic perturbations. Evolutionary capacitors modulate the amount of genetic variation exposed to natural selection and hidden cryptically; they have a fundamental effect on the evolvability of traits on evolutionary timescales. In this study, I have demonstrated the effects of multiple genomic regions of Drosophila melanogaster on CGV in wing shape. I examined the effects of 61 genomic deficiencies on quantitative and qualitative natural genetic variation in the wing shape of D. melanogaster. I have identified 10 genomic deficiencies that do not encompass a known candidate evolutionary capacitor, Hsp90, exposing natural CGV differently depending on the location of the deficiencies in the genome. Furthermore, five genomic deficiencies uncovered qualitative CGV in wing morphology. These findings suggest that CGV in wing shape of wild-type D. melanogaster is regulated by multiple capacitors with divergent functions. Future analysis of genes encompassed by these genomic regions would help elucidate novel capacitor genes and better understand the general features of capacitors regarding natural genetic variation.
当生物体的稳健性受到环境或遗传干扰而受损时，隐藏的遗传变异（CGV）或常态下不表现为表型的遗传变异就会释放出来。进化电容器调节了暴露于自然选择和隐藏的遗传变异的数量；它们对进化时间尺度上的性状可进化性具有根本影响。在这项研究中，我展示了果蝇多个基因组区域对翅膀形状 CGV 的影响。我检查了 61 个基因组缺失对果蝇翅膀形状的定量和定性自然遗传变异的影响。我确定了 10 个基因组缺失不包含已知的候选进化电容器 Hsp90，这些缺失根据其在基因组中的位置不同，对自然 CGV 的影响也不同。此外，五个基因组缺失揭示了翅膀形态的定性 CGV。这些发现表明，野生型果蝇翅膀形状的 CGV 受到具有不同功能的多个电容器的调节。对这些基因组区域所包含的基因进行进一步分析，将有助于阐明新的电容器基因，并更好地了解电容器在自然遗传变异方面的一般特征。
