Hulthen U L, Toremalm N G
J Otolaryngol. 1976 Feb;5(1):55-63.
A case of juvenile nasopharyngeal angiofibroma in a 14 year old boy is presented on account of the endocrinological investigation performed before, during, and after treatment with 15 mg/day diethylstilbestrol for more than one month. Previously, the tumor had recurred in spite of extensive surgery. Secondary sexual characteristics were normal and the development of puberty at the age of 12-13 years seemed not to have influenced tumor growth. In contrast to certain previous reports, normal functions were found regarding the pituitary, the gonads, the adrenal cortex, and the thyroid gland in our patient. The tumor continued to grow in spite of the diethylstilbestrol therapy.
本文报告一例14岁男孩的青少年鼻咽血管纤维瘤病例，该病例是基于在使用15毫克/天己烯雌酚治疗超过一个月之前、治疗期间和治疗之后所进行的内分泌学检查。此前，尽管进行了广泛的手术，肿瘤仍复发。患者的第二性征正常，12 - 13岁时青春期的发育似乎并未影响肿瘤生长。与之前的某些报道相反，我们的患者在垂体、性腺、肾上腺皮质和甲状腺方面功能正常。尽管进行了己烯雌酚治疗，但肿瘤仍持续生长。
