Keihani-Doust Zarrin, Saeedi Maryam, Esmaeilni Tahere, Habibi Massoud, Nazari Seyed Saeed Hashemi
1Department of Pediatrics, Imam Hospital, Tehran University of Medical Sciences, Tehran, Iran.
J Child Neurol. 2013 Dec;28(12):1555-61. doi: 10.1177/0883073812461564. Epub 2012 Oct 30.
Birth asphyxia is one of the multiple causes of neonatal encephalopathy. The objective of this study was to evaluate neurodevelopmental outcomes of newborn term infants with definitive asphyxia. Thirty infants met study criteria for asphyxia. The 5-year incidence of asphyxia was estimated to be 5.5 in 1000. According to the Age and Stage Questionnaire, 10.5% of 6-month-old infants, 14.3% of 12- and 18-month-old infants, and 5.3% of 24-month-old infants had neurodevelopmental delay in gross motor function in the absence of cerebral palsy. In 7.3% of 18-month-old infants, neurodevelopmental delay in problem-solving ability was observed. Higher values of Apgar score and bicarbonate levels were associated with higher Age and Stage Questionnaire total score. Delivery type, maternal age, gravidity of mother, and existence of mother disease during pregnancy were also associated with lower Age and Stage Questionnaire total score in different stages of life.
出生窒息是新生儿脑病的多种病因之一。本研究的目的是评估确诊为窒息的足月儿的神经发育结局。30名婴儿符合窒息的研究标准。窒息的5年发病率估计为每1000例中有5.5例。根据年龄与发育进程问卷，在无脑瘫的情况下，6个月大婴儿中有10.5%、12个月和18个月大婴儿中有14.3%、24个月大婴儿中有5.3%在粗大运动功能方面存在神经发育延迟。在18个月大的婴儿中，有7.3%观察到解决问题能力方面的神经发育延迟。阿氏评分和碳酸氢盐水平较高与年龄与发育进程问卷总分较高相关。分娩方式、母亲年龄、母亲妊娠次数以及孕期母亲疾病的存在在不同生命阶段也与年龄与发育进程问卷总分较低相关。
