Tyurenkov I N, Borodkina L E, Bagmetova V V
Volgograd State Medical University, Russia.
Bull Exp Biol Med. 2012 Sep;153(5):710-3. doi: 10.1007/s10517-012-1806-5.
New salts of baclofen (4-amino-3-(para-chlorophenyl)-butyric acid) and its compositions with organic carbonic acids (citric, succinic, malic, oxalic, nicotinic, glutamic acids and glycine) exhibited neuroprotective and anticonvulsive effects. They reduced the intensity of the convulsive syndrome and postconvulsive psychoneurological disorders in animals exposed to the maximum electroshock and electroconvulsive shock. Analogs of baclofen containing citrate and to a lesser extent those containing glutamate and glycine were significantly more active than the initial substance.
巴氯芬（4-氨基-3-（对氯苯基）-丁酸）与有机碳酸（柠檬酸、琥珀酸、苹果酸、草酸、烟酸、谷氨酸和甘氨酸）形成的新盐及其组合物具有神经保护和抗惊厥作用。它们降低了接受最大电击和电惊厥休克的动物的惊厥综合征强度和惊厥后精神神经障碍。含柠檬酸盐的巴氯芬类似物以及含谷氨酸和甘氨酸程度较低的类似物比初始物质活性明显更高。
