Kisarova Ya A, Korolenko T A
Institute of Physiology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk.
Bull Exp Biol Med. 2012 Oct;153(6):874-7. doi: 10.1007/s10517-012-1848-8.
We studied the content of tissue inhibitors of matrix metalloproteinases 1 and 2 (TIMP-1 and TIMP-2) and activities of matrix metalloproteinases (MMP) in the serum and lungs of mice with Lewis lung carcinoma metastasizing into the lung. Metastasizing was associated with increased serum content of TIMP-1 and TIMP-2 (only on day 20 at the terminal stage of the tumor process). These data confirm the hypothesis on pro-tumorigenic role of TIMP-1 in the serum. Locally, the development of metastases was associated with a decrease in TIPM-1 concentration (day 7), an increase in TIMP-2 concentration (days 7 and 20), and elevated activity of MMP at all terms of the study (days 7, 15, and 20). Increased concentration of TIMP-2 in the lungs (but not in the serum) can be regarded as an indicator of Lewis lung carcinoma metastasizing.
我们研究了Lewis肺癌肺转移小鼠血清和肺组织中基质金属蛋白酶组织抑制剂1和2（TIMP-1和TIMP-2）的含量以及基质金属蛋白酶（MMP）的活性。肿瘤转移与血清中TIMP-1和TIMP-2含量增加有关（仅在肿瘤进程末期的第20天）。这些数据证实了血清中TIMP-1具有促肿瘤作用的假说。在局部，转移灶的形成与TIMP-1浓度降低（第7天）、TIMP-2浓度升高（第7天和第20天）以及研究各阶段（第7天、第15天和第20天）MMP活性升高有关。肺组织（而非血清）中TIMP-2浓度升高可被视为Lewis肺癌发生转移的一个指标。
