Department of Ophthalmology, Kitasato University School of Medicine, Kanagawa, Japan.
J Ocul Pharmacol Ther. 2013 Apr;29(3):356-9. doi: 10.1089/jop.2012.0098. Epub 2012 Oct 31.
To investigate clinically the effects of yeast-fermented bilberry extract on visual outcomes in myopic eyes.
In a prospective, randomized, placebo-controlled, cross-over study, we examined 30 eyes of 30 middle-aged healthy volunteers (mean age±standard deviation, 39.5±7.2 years) with myopia [manifest spherical equivalent, -2.40±1.88 diopters (D)], who were randomly assigned to 1 of 2 oral regimens: fermented bilberry extract (400 mg/day) or placebo. We quantitatively assessed visual acuity, refraction, pupil constriction rate, accommodation, and mesopic contrast sensitivity (CS), before and 1 month after treatment. Only the right eyes were tested. The amplitude of accommodation and CS were measured with an accommodometer (D'ACOMO; WOC) and a CS unit (VCTS-6500; Vistech), respectively. From the CS, the area under the log contrast sensitivity function (AULCSF) was calculated.
The mean amplitude of accommodation increased significantly, from 4.62±1.88 D before treatment, to 5.33±2.03 D after treatment in the study group (Wilcoxon signed-rank test, P=0.002). Moreover, the mesopic AULCSF was significantly increased, from 1.04±0.16 before, to 1.13±0.17 after, treatment (P=0.009). However, we found no significant changes in accommodation or AULCSF in the control group (P>0.05), or any significant changes in any other parameters in either group (P>0.05).
The present data show that fermented bilberry extract is effective in causing increases in subjective accommodation and in mesopic CS in myopic eyes.
研究酵母发酵越橘提取物对近视眼视觉效果的临床影响。
在一项前瞻性、随机、安慰剂对照、交叉研究中，我们检查了 30 名中年健康志愿者（平均年龄±标准差，39.5±7.2 岁）的 30 只近视眼[表现为等效球镜，-2.40±1.88 屈光度（D）]，他们被随机分配到 2 种口服方案之一：发酵越橘提取物（400 mg/天）或安慰剂。我们在治疗前和治疗后 1 个月分别定量评估了视力、屈光度、瞳孔收缩率、调节和中值对比敏感度（CS）。仅对右眼进行了测试。调节幅度和 CS 分别用调节计（D'ACOMO；WOC）和 CS 单元（VCTS-6500；Vistech）进行测量。从中值 CS 计算 log 对比敏感度函数下的面积（AULCSF）。
研究组的平均调节幅度从治疗前的 4.62±1.88 D 显著增加到治疗后的 5.33±2.03 D（Wilcoxon 符号秩检验，P=0.002）。此外，中值 AULCSF 从治疗前的 1.04±0.16 显著增加到治疗后的 1.13±0.17（P=0.009）。然而，我们在对照组中没有发现调节或 AULCSF 的显著变化（P>0.05），或者两组中任何其他参数的显著变化（P>0.05）。
目前的数据表明，发酵越橘提取物能有效引起近视眼主观调节和中值 CS 的增加。
