肝脏冷冻手术中的冷冻过程及损伤机制。

The process of freezing and the mechanism of damage during hepatic cryosurgery.

作者信息

Rubinsky B, Lee C Y, Bastacky J, Onik G

机构信息

Department of Mechanical Engineering, University of California, Berkeley 94720.

出版信息

Cryobiology. 1990 Feb;27(1):85-97. doi: 10.1016/0011-2240(90)90055-9.

DOI:10.1016/0011-2240(90)90055-9

PMID:2311412

Abstract

Experiments were performed to correlate the structures of liver tissue frozen during cryosurgery, liver frozen at various constant cooling rates, and unfrozen, dried normal liver. The results show that during freezing of tissue ice forms and propagates along the vascular system, expanding during freezing at low cooling rates. This expansion occurs over most of the region frozen during cryosurgery and may be one of the mechanisms of damage to tissue during cryosurgery.

摘要

进行了多项实验，以关联冷冻手术期间冷冻的肝组织、在不同恒定冷却速率下冷冻的肝脏以及未冷冻、干燥的正常肝脏的结构。结果表明，在组织冷冻过程中，冰形成并沿血管系统扩散，在低冷却速率下冷冻时会膨胀。这种膨胀发生在冷冻手术期间冷冻的大部分区域，可能是冷冻手术期间组织损伤的机制之一。