Gulian J M, Dalmasso C, Gonard V
Laboratoire de Chimie Biologique, Faculté de Médecine, Marseille, France.
Chemotherapy. 1990;36(2):91-7. doi: 10.1159/000238753.
The effects of 'third-generation' cephalosporins and penicillin analogues on the concentrations of total unconjugated bilirubin, unbound bilirubin and erythrocyte-bound bilirubin were determined in blood samples. This study was performed, in vitro, at two bilirubin/albumin molar ratios and at various concentrations of antibiotics. The most effective displacers, considering the three methods, were antibiotics tightly bound to albumin: ceftriaxone and cefotetan. Cefoperazone, which is bound to albumin as tightly as these two antibiotics, caused no significant increase in unbound bilirubin but should be considered as a displacer drug on the basis of the variations of erythrocyte-bound bilirubin and total bilirubin. We suggest that drug interaction on bilirubin-albumin binding be investigated by several methods.
在血样中测定了“第三代”头孢菌素和青霉素类似物对总未结合胆红素、游离胆红素和红细胞结合胆红素浓度的影响。本研究在体外以两种胆红素/白蛋白摩尔比和不同抗生素浓度进行。综合三种方法来看，最有效的置换剂是与白蛋白紧密结合的抗生素：头孢曲松和头孢替坦。头孢哌酮与这两种抗生素一样紧密结合白蛋白，未导致游离胆红素显著增加，但基于红细胞结合胆红素和总胆红素的变化应被视为置换药物。我们建议通过多种方法研究药物与胆红素 - 白蛋白结合的相互作用。
