III 期结直肠癌中的胸苷磷酸化酶基因表达。
Thymidine Phosphorylase Gene Expression in Stage III Colorectal Cancer.
机构信息
Department of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Sahlgrenska University Hospital/Östra, Gothenburg, Sweden.
出版信息
Clin Med Insights Oncol. 2012;6:347-53. doi: 10.4137/CMO.S10226. Epub 2012 Oct 15.
BACKGROUND
The thymidine phosphorylase (TP) enzyme has several tumor-promoting functions. The aim of this study was to explore TP gene expression in relation to clinical and histopathological data obtained from patients with stage III colorectal cancer.
METHODS AND RESULTS
TP gene expression was analyzed by real-time quantitative PCR in tumor and mucosa samples from 254 patients. TP gene expression in tumors correlated with lymph node staging, with higher expression relating to a higher number of positive nodes and a worse N-stage. Higher TP expression was also associated with a worse histological tumor grade. Patients with rectal cancer had significantly higher TP expression in mucosa and tumors compared with patients having colon cancer.
CONCLUSION
Higher intratumoral TP expression appears to be related to a worse N stage, and thus, with a worse prognosis. TP gene expression measured in a preoperative biopsy could be of interest in preoperative staging.
背景
胸苷磷酸化酶（TP）酶具有多种促进肿瘤生长的功能。本研究旨在探讨 TP 基因表达与 III 期结直肠癌患者的临床和组织病理学数据之间的关系。
方法和结果
对 254 例患者的肿瘤和黏膜样本进行实时定量 PCR 分析 TP 基因表达。肿瘤中 TP 基因表达与淋巴结分期相关，阳性淋巴结数量越多，N 分期越高，TP 表达越高。较高的 TP 表达也与较差的组织学肿瘤分级相关。与结肠癌患者相比，直肠癌患者的黏膜和肿瘤中 TP 表达明显更高。
结论
肿瘤内 TP 表达较高似乎与较差的 N 期相关，从而与预后不良相关。术前活检中测量的 TP 基因表达可能对术前分期有意义。
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