介导卡巴胆碱对鸡胚心室正性变力作用的毒蕈碱受体对哌仑西平的亲和力较低。
Muscarinic receptors mediating the positive inotropic effect of carbachol in embryonic chick ventricle have a low affinity for pirenzepine.
作者信息
Protas L L
机构信息
Sechenov Institute of Evolutionary Physiology and Biochemistry, USSR Academy of Sciences, Leningrad.
出版信息
Eur J Pharmacol. 1990 Jan 10;175(2):215-8. doi: 10.1016/0014-2999(90)90234-w.
Electrically driven ventricular strips from 3 day old chick embryos were used to investigate the ability of pirenzepine, a muscarinic antagonist that distinguishes between subtypes of muscarinic receptors, to antagonize the positive inotropic effect of carbachol. A low pA2 value was found for pirenzepine (6.40) whereas the pA2 value for atropine was 1000-fold higher (9.36). It can be concluded that the positive inotropic effect of carbachol on this tissue is mediated by muscarinic receptors others than M1-receptors.
使用3日龄鸡胚的电驱动心室肌条来研究哌仑西平（一种能区分毒蕈碱受体亚型的毒蕈碱拮抗剂）拮抗卡巴胆碱正性肌力作用的能力。发现哌仑西平的pA2值较低（6.40），而阿托品的pA2值则高1000倍（9.36）。可以得出结论，卡巴胆碱对该组织的正性肌力作用是由M1受体以外的毒蕈碱受体介导的。
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