Schache Maria, Baird Paul N
Royal Victorian Eye And Ear Hospital, University Of Melbourne, Australia.
Twin Res Hum Genet. 2013 Feb;16(1):52-7. doi: 10.1017/thg.2012.96. Epub 2012 Nov 2.
The Australian Twin Registry (ATR) is a not-for-profit organization that coordinates research involving Australian twins and researchers. The ATR is one of the largest volunteer registries of its kind and contains over 33,000 twin pairs. The purpose of this review is to provide a broad overview of recent ophthalmic studies that have utilized the ATR for recruitment purposes. Such studies include the Australian Twin Eye Study (ATES) and the Genes in Myopia (GEM) study. The ATES and GEM studies have undertaken studies into the genetic influences on a number of ophthalmic traits through the use of heritability studies, linkage studies, genome-wide association studies, and candidate gene-based studies. An overview of these studies is provided in this review, as well as a description of the recruitment methodologies for both the ATES and GEM studies.
澳大利亚双胞胎登记处（ATR）是一个非营利性组织，负责协调涉及澳大利亚双胞胎和研究人员的研究。ATR是同类中最大的志愿者登记处之一，包含超过33000对双胞胎。本综述的目的是对最近利用ATR进行招募的眼科研究进行广泛概述。此类研究包括澳大利亚双胞胎眼研究（ATES）和近视基因（GEM）研究。ATES和GEM研究通过使用遗传力研究、连锁研究、全基因组关联研究和基于候选基因的研究，对多种眼科特征的遗传影响进行了研究。本综述提供了这些研究的概述，以及ATES和GEM研究的招募方法描述。
