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妊娠期胃肠道外间质瘤

Extragastrointestinal Stromal Tumor during Pregnacy.

作者信息

Gözükara Ilay, Dilek T U Kutlu, Durukan Hüseyin, Düsmez Apa Duygu, Kabil Kucur Suna, Dilek Saffet

机构信息

Obstetric and Gynecology Department, Erzurum Nenehatun Obstetric and Gynecology Hospital, Erzurum, Turkey.

出版信息

Case Rep Obstet Gynecol. 2012;2012:846747. doi: 10.1155/2012/846747. Epub 2012 Oct 18.

DOI:10.1155/2012/846747
PMID:23119199
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3483706/
Abstract

Extragastrointestinal stromal tumors (EGISTs) are mesenchymal neoplasms without connection to the gastrointestinal tract. Gastrointestinal stromal tumors (GISTs) and EGIST are similar according to their clinicopathologic and histomorphologic features. Both of them most often express immunoreactivity for CD-117, a c-kit proto-oncogene protein. The coexistence of GIST and pregnancy is very rare, with only two cases reported in the literature. In this paper, we presented the first EGIST case during pregnancy in the literature.

摘要

胃肠道外间质瘤（EGISTs）是一种与胃肠道无关联的间叶性肿瘤。胃肠道间质瘤（GISTs）和EGIST在临床病理及组织形态学特征方面相似。它们大多都对CD - 117（一种c - kit原癌基因蛋白）呈免疫反应阳性。GIST与妊娠并存的情况非常罕见，文献中仅报道过两例。在本文中，我们呈现了文献中首例妊娠期EGIST病例。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a49/3483706/2ceba9e7a0fb/CRIM.OBGYN2012-846747.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a49/3483706/3c329f8a12a2/CRIM.OBGYN2012-846747.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a49/3483706/2ceba9e7a0fb/CRIM.OBGYN2012-846747.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a49/3483706/3c329f8a12a2/CRIM.OBGYN2012-846747.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a49/3483706/2ceba9e7a0fb/CRIM.OBGYN2012-846747.002.jpg

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1
Extragastrointestinal Stromal Tumor during Pregnacy.妊娠期胃肠道外间质瘤
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引用本文的文献

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An update on gastrointestinal stromal tumors (GISTs) with a focus on extragastrointestinal stromal tumors (EGISTs).胃肠道间质瘤（GISTs）的最新进展，重点关注胃肠道外间质瘤（EGISTs）。
Gastroenterol Rep (Oxf). 2025 Jul 23;13:goaf068. doi: 10.1093/gastro/goaf068. eCollection 2025.
2
Diagnosis and management of high risk gastrointestinal stromal tumor in first trimester pregnancy: A case report and review of the literature.孕早期高危胃肠道间质瘤的诊断与管理：一例病例报告及文献综述
Heliyon. 2023 May 9;9(5):e15858. doi: 10.1016/j.heliyon.2023.e15858. eCollection 2023 May.
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A rare maternal gastrointestinal stromal tumor found in the second trimester of pregnancy: A case report.

本文引用的文献

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Unusually large extraintestinal GIST presenting as an abdomino-pelvic tumor.表现为腹盆腔肿瘤的异常巨大的肠外胃肠道间质瘤。
Arch Gynecol Obstet. 2008 Jul;278(1):89-92. doi: 10.1007/s00404-007-0528-9. Epub 2007 Dec 8.
2
Extragastrointestinal stromal tumor mimicking a uterine tumor. A rare clinical entity.模仿子宫肿瘤的胃肠道外间质瘤。一种罕见的临床实体。
Int J Gynecol Cancer. 2008 Sep-Oct;18(5):1115-8. doi: 10.1111/j.1525-1438.2007.01121.x. Epub 2007 Nov 6.
3
Extragastrointestinal stromal tumors presenting as vulvovaginal/rectovaginal septal masses: a diagnostic pitfall.
孕期中期发现的罕见母体胃肠道间质瘤：一例报告
Case Rep Womens Health. 2020 Aug 22;28:e00251. doi: 10.1016/j.crwh.2020.e00251. eCollection 2020 Oct.
4
A Novel Fusion in Gastrointestinal Stromal Tumor Guides Adjuvant Treatment Decision-Making During Pregnancy.胃肠道间质瘤中的一种新型融合指导妊娠期间的辅助治疗决策。
J Natl Compr Canc Netw. 2018 Mar;16(3):238-242. doi: 10.6004/jnccn.2017.7039.
5
Bone and soft tissue sarcomas during pregnancy: A narrative review of the literature.孕期骨肉瘤和软组织肉瘤：文献综述
J Adv Res. 2016 Jul;7(4):581-7. doi: 10.1016/j.jare.2016.01.003. Epub 2016 Feb 2.
6
Gastrointestinal stromal tumors during pregnancy: a systematic review of an uncommon but treatable malignancy.妊娠期间的胃肠道间质瘤：对一种罕见但可治疗的恶性肿瘤的系统评价
Clin Transl Oncol. 2015 Oct;17(10):757-62. doi: 10.1007/s12094-015-1315-x. Epub 2015 Jun 9.
表现为外阴阴道/直肠阴道隔肿物的胃肠道外间质瘤：一个诊断陷阱
Int J Gynecol Pathol. 2006 Jul;25(3):288-92. doi: 10.1097/01.pgp.0000215291.22867.18.
4
Reclassification of a tubal leiomyosarcoma as an eGIST by molecular evaluation of c-KIT.通过对c-KIT进行分子评估，将一例输卵管平滑肌肉瘤重新分类为胃肠道间质瘤。
Gynecol Oncol. 2006 May;101(2):363-6. doi: 10.1016/j.ygyno.2005.12.022. Epub 2006 Jan 24.
5
About a case of GIST occurring during pregnancy with immunohistochemical expression of epidermal growth factor receptor and progesterone receptor.关于一例孕期发生的胃肠道间质瘤伴表皮生长因子受体和孕激素受体免疫组化表达的病例。
Pathol Res Pract. 2006;202(2):119-23. doi: 10.1016/j.prp.2005.08.013. Epub 2006 Jan 18.
6
Clinicopathological and immunohistochemical features of extragastrointestinal stromal tumors: report of two cases.胃肠道外间质瘤的临床病理及免疫组化特征：附2例报告
Surg Today. 2005;35(4):336-40. doi: 10.1007/s00595-004-2932-0.
7
Primary gastrointestinal stromal tumors in the omentum and mesentery: CT findings and pathologic correlations.大网膜和肠系膜原发性胃肠道间质瘤：CT表现与病理对照
AJR Am J Roentgenol. 2004 Jun;182(6):1463-7. doi: 10.2214/ajr.182.6.1821463.
8
c-kit and PDGFRA mutations in extragastrointestinal stromal tumor (gastrointestinal stromal tumor of the soft tissue).胃肠道外间质瘤（软组织胃肠道间质瘤）中的c-kit和PDGFRA突变
Am J Surg Pathol. 2004 Apr;28(4):479-88. doi: 10.1097/00000478-200404000-00007.
9
Extragastrointestinal (soft tissue) stromal tumors: an analysis of 48 cases with emphasis on histologic predictors of outcome.胃肠道外（软组织）间质瘤：48例病例分析，重点关注预后的组织学预测指标。
Mod Pathol. 2000 May;13(5):577-85. doi: 10.1038/modpathol.3880099.