Mitra D, Basu S, Deb A R, Rashid M A, Sur P K
Department of Radiotherapy, N.R.S. Medical College, Kolkata.
Indian J Otolaryngol Head Neck Surg. 2006 Oct;58(4):360-3. doi: 10.1007/BF03049595.
To study the efficacy of neo-adjuvant chemotherapy followed by radiotherapy in advanced head and neck cancer.
Randomised, prospective study.
Tertiary academic referral center.
One hundred and eighty patients of advanced head and neck squamous cell carcinoma.
PATIENTS were randomized into two arms. The study arm (CT-RT arm) received 3 cycles of anterior chemotherapy with Inj. Cisplatin 100 mg/m(2) on D(1) and Inj 5F.U. 700 mg/m(2) on D(1)-D(4) at an interval of 21 days, followed by external radiation. The control arm (RT arm) received external radiotherapy only. The dose of Radiotherapy was 64 to 68 Gy in conventional fractionation.
PATIENTS of CT-RT showed better tumour control locally than patients who received only RT. Toxicities were commoner in CT-RT arm but they were manageable. 5 year survival is higher in the CT-RT arm (21% vs 16%; p value> 0.05).
Anterior chemotherapy with Cisplatin and 5F.U. is associated with good clinical response which is translated into increased survival along with acceptable toxicities.
研究新辅助化疗联合放疗在晚期头颈癌中的疗效。
随机、前瞻性研究。
三级学术转诊中心。
180例晚期头颈鳞状细胞癌患者。
患者被随机分为两组。研究组（CT-RT组）接受3个周期的前期化疗，顺铂注射液100mg/m²于第1天给药，5-氟尿嘧啶注射液700mg/m²于第1天至第4天给药，每21天为一个周期，随后进行外照射放疗。对照组（RT组）仅接受外照射放疗。放疗剂量为64至68Gy，采用常规分割。
CT-RT组患者的局部肿瘤控制情况优于仅接受放疗的患者。CT-RT组的毒性反应更常见，但可以控制。CT-RT组的5年生存率更高（21%对16%；p值>0.05）。
顺铂和5-氟尿嘧啶的前期化疗具有良好的临床反应，可提高生存率，且毒性反应可接受。
