Chinagudi Surekharani, Patted Shiddanna M, Herur Anita
Department of Physiology, S. N. Medical College, Navanagar, Bagalkot, 587103 India.
Indian J Otolaryngol Head Neck Surg. 2010 Jan;62(1):44-8. doi: 10.1007/s12070-010-0008-6. Epub 2010 Jun 4.
There is evidence of cardiac abnormalities in congenital deaf school children, together called as Jervel Lange Nielsen syndrome or Long QT syndrome.
The main aim was to study the electrocardiographic changes in congenital deaf children.
Fifty congenital deaf children aged 6-18 years were selected. ECG was taken in lead II, at rest and after exercise, as some are known to exhibit the abnormality after exercise. The child was made to run on the Tread mill till exhaustion. Corrected QT interval (QTc) was Calculated by Bazett's formula QTc = QT/ √R-R. ECG was also analyzed for other abnormalities like Twave changes, ST depression, rhythm abnormalities etc.
Out of 50, 2 children showed resting QTc of 0.45 sec which is diagnostically high. Mean value of QTc in deaf children(Cases) before exercise was 0.4111 ± 0.0271 sec and in controls 0.379 ± 0.020 sec. Mean value of QTc after exercise in deaf(cases) was 0.403 ± 0.028 sec and in controls 0.376 ± 0.021 sec. Eight deaf children showed ST depression and 2 biphasic T and 2 notched T waves. Thirty-three deaf children's parents had consanguineous marriage.
The results were explained on the basis of ion channellopathy in heart and inner ear which predisposes to sensorineural hearing loss and cardiac abnormality.
有证据表明先天性失聪学童存在心脏异常，统称为耶尔韦尔 - 朗格 - 尼尔森综合征或长QT综合征。
主要目的是研究先天性失聪儿童的心电图变化。
选取50名6至18岁的先天性失聪儿童。在静息和运动后记录II导联心电图，因为已知一些儿童在运动后会出现异常。让儿童在跑步机上跑步直至疲惫。通过巴泽特公式QTc = QT / √R - R计算校正QT间期（QTc）。还对心电图分析其他异常情况，如T波改变、ST段压低、节律异常等。
50名儿童中，2名儿童静息QTc为0.45秒，具有诊断意义的高值。失聪儿童（病例组）运动前QTc平均值为0.4111±0.0271秒，对照组为0.379±0.020秒。失聪儿童（病例组）运动后QTc平均值为0.403±0.028秒，对照组为0.376±0.021秒。8名失聪儿童出现ST段压低，2名出现双相T波，2名出现切迹T波。33名失聪儿童的父母有近亲婚姻。
结果是基于心脏和内耳的离子通道病来解释的，这种疾病易导致感音神经性听力损失和心脏异常。
