Onyesom I, Inmuere F, Awhin P E
East Afr J Public Health. 2011 Sep;8(3):212-5.
A total of seventy (70) consenting subjects were recruited for this study. The subjects consist of fifty (50) hypertensive subjects yet to receive treatment and twenty (20) normotensive (control) subjects. Subjects' blood pressure values were measured and serum was obtained from the whole blood collected by vene puncture using centrifugation technique. Serum calcium, phosphorus and magnesium were determined by established procedures using commercial kit reagents. Results show that the mean serum calcium, phosphorus and magnesium levels for hypertensive patients were 1.98 +/- 0.22 mmol/L, 1.65 +/- 0.42 mmol/L and 0.88 +/- 0.20 mmol/L as against 2.11 +/- 0.10 mmol/L, 1.50 +/- 0.12 mmol/L and 0.96 +/- 0.05 mmol/L for normotensive subjects. Fifty-four (54) percent and twelve (12) percent of the hypertensives had reduced calcium and magnesium levels respectively, but none for the normotensive subjects. Fifty-eight (58) percent of the hypertensive patients and forty-five (45) percent of the normotensives had elevated serum phosphorus levels, but no subject was hypophophataemic. Hypertension reduced serum calcium (P < 0.05) and magnesium (P > 0.05) levels among hypertensives in the south-south area of Nigeria. These micronutrients are therefore implicated in the progression of hypertension. These micronutrients are therefore implicated in the progression of hypertension. The effects of antihypertensive drugs and/or micronutrients' supplementation on blood pressure and serum calcium, phosphorous and magnesium levels in our study area should be further investigated. This is important because beneficial adjunct to the available modalities in the treatment of hypertension especially in Nigeria could be identified.
本研究共招募了70名同意参与的受试者。受试者包括50名尚未接受治疗的高血压患者和20名血压正常（对照）的受试者。测量了受试者的血压值，并通过静脉穿刺采血，采用离心技术从全血中获取血清。使用商业试剂盒试剂，通过既定程序测定血清钙、磷和镁。结果显示，高血压患者的血清钙、磷和镁平均水平分别为1.98±0.22 mmol/L、1.65±0.42 mmol/L和0.88±0.20 mmol/L，而血压正常受试者的这三项指标分别为2.11±0.10 mmol/L、1.50±0.12 mmol/L和0.96±0.05 mmol/L。分别有54%和12%的高血压患者钙和镁水平降低，但血压正常受试者中无此情况。58%的高血压患者和45%的血压正常受试者血清磷水平升高，但无受试者出现低磷血症。在尼日利亚南南地区，高血压降低了高血压患者的血清钙水平（P<0.05）和镁水平（P>0.05）。因此，这些微量营养素与高血压的进展有关。因此，这些微量营养素与高血压的进展有关。应进一步研究抗高血压药物和/或微量营养素补充剂对我们研究地区血压以及血清钙、磷和镁水平的影响。这很重要，因为这样可以确定对现有高血压治疗方式有益的辅助手段，尤其是在尼日利亚地区。
