Liance M, Bresson-Hadni S, Vuitton D, Bretagne S, Houin R
Laboratoire de Parasitologie, Faculté du Médecine de Créteil, France.
Int J Parasitol. 1990 Feb;20(1):83-6. doi: 10.1016/0020-7519(90)90177-o.
Alveolar echinococcosis, due to E. multilocularis, is usually a fatal disease in patients whether treated by benzimidazolecarbamates or not. However, aborted infections have been described, suggesting the existence of strains of parasites of varying pathogenicity. These observations led us to analyse the viability of larvae in 20 patients. After observation of human lesions, the viability of metacestodes was tested by intraperitoneal infection in two intermediate host species, Meriones unguiculatus and AKR inbred mice. Parasitic development was more frequent in mice than in M. unguiculatus, but in the latter, growth was more rapid and the larval mass produced was greater. Isolates which originated from patients undergoing treatment had an abortive growth; two others were characterized by a steady, though slow, development, producing a poorly budding larva; lastly there were some which were morphologically similar with a multivesicular appearance but differing development times. These results may serve as a guide for more basic studies leading to an understanding of the problem of intraspecific variations in E. multilocularis.
由多房棘球绦虫引起的肺泡型棘球蚴病，无论患者是否接受苯并咪唑类药物治疗，通常都是一种致命疾病。然而，已有感染中止的病例报道，这表明存在致病性不同的寄生虫菌株。这些观察结果促使我们分析20例患者体内幼虫的活力。在观察人体病变后，通过将包虫囊蚴腹腔接种到两种中间宿主物种（长爪沙鼠和AKR近交系小鼠）中，检测其活力。寄生虫在小鼠体内的发育比在长爪沙鼠体内更常见，但在长爪沙鼠体内，生长更快，产生的幼虫团更大。来自正在接受治疗患者的分离株生长中止；另外两株的特征是发育稳定但缓慢，产生的幼虫芽生不良；最后，还有一些在形态上相似，呈多泡状外观，但发育时间不同。这些结果可为更基础的研究提供指导，从而有助于理解多房棘球绦虫种内变异问题。
