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腺苷对大鼠海马切片诱发电位及环磷酸腺苷积累影响的平行研究。

Parallel investigations of the effects of adenosine on evoked potentials and cyclic AMP accumulation in hippocampus slices of the rat.

作者信息

Reddington M, Schubert P

出版信息

Neurosci Lett. 1979 Sep;14(1):37-42. doi: 10.1016/0304-3940(79)95340-0.

DOI:10.1016/0304-3940(79)95340-0
PMID:231229
Abstract

In slices of rat hippocampus, adenosine and its receptor agonist, 2-chloro-adenosine, were both found to (a) enhance the intracellular accumulation of cyclic adenosine monophosphate (cAMP) and (b) depress neuronal evoked responses to electrical stimulation. The differences in the dose/effect curves for the biochemical and electrophysiological changes cast doubt on a causal relationship between the two effects.

摘要

在大鼠海马体切片中,已发现腺苷及其受体激动剂2-氯腺苷均能:(a)增强细胞内环磷酸腺苷(cAMP)的积累;(b)抑制神经元对电刺激的诱发反应。生化和电生理变化的剂量/效应曲线差异使人怀疑这两种效应之间的因果关系。

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1
Parallel investigations of the effects of adenosine on evoked potentials and cyclic AMP accumulation in hippocampus slices of the rat.腺苷对大鼠海马切片诱发电位及环磷酸腺苷积累影响的平行研究。
Neurosci Lett. 1979 Sep;14(1):37-42. doi: 10.1016/0304-3940(79)95340-0.
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An A1-adenosine receptor, characterized by [3H] cyclohexyladenosine binding, mediates the depression of evoked potentials in a rat hippocampal slice preparation.一种通过[3H]环己基腺苷结合来表征的A1-腺苷受体,介导大鼠海马切片制备中诱发电位的抑制。
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Adenine nucleotides and synaptic transmission in the in vitro rat hippocampus.体外大鼠海马体中的腺嘌呤核苷酸与突触传递
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In vivo pertussis toxin treatment attenuates some, but not all, adenosine A1 effects in slices of the rat hippocampus.体内百日咳毒素处理可减弱大鼠海马切片中部分而非全部的腺苷A1效应。
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Effect of adenosine versus adenine nucleotides on evoked potentials in a rat hippocampal slice preparation.
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Alpha-adrenoceptor stimulation, but not muscarinic stimulation, increases cyclic AMP accumulation in brain slices due to protein kinase C mediated enhancement of adenosine receptor effects.α-肾上腺素能受体刺激而非毒蕈碱样刺激可增加脑切片中环磷酸腺苷(cAMP)的积累,这是由于蛋白激酶C介导的腺苷受体效应增强所致。
Acta Physiol Scand. 1987 Dec;131(4):543-51. doi: 10.1111/j.1748-1716.1987.tb08274.x.

引用本文的文献

1
Inhibition by purines of the inotropic action of isoprenaline in rat atria.嘌呤对大鼠心房中异丙肾上腺素变力作用的抑制作用。
Br J Pharmacol. 1983 Sep;80(1):149-53. doi: 10.1111/j.1476-5381.1983.tb11060.x.
2
The ionic basis of adenosine receptor actions on post-ganglionic neurones in the rat.腺苷受体对大鼠节后神经元作用的离子基础。
J Physiol. 1983 Mar;336:607-20. doi: 10.1113/jphysiol.1983.sp014600.
3
Purine receptors in the rat anococcygeus muscle.大鼠肛尾肌中的嘌呤受体。
J Physiol. 1983 Feb;335:591-608. doi: 10.1113/jphysiol.1983.sp014553.
4
Organic calcium channel blockers enhance [3H]purine release from rat brain cortical synaptosomes.有机钙通道阻滞剂可增强大鼠脑皮质突触体中[3H]嘌呤的释放。
Neurochem Res. 1984 Aug;9(8):1019-31. doi: 10.1007/BF00964798.
5
Adenosine receptors mediating inhibitory electrophysiological responses in rat hippocampus are different from receptors mediating cyclic AMP accumulation.介导大鼠海马体抑制性电生理反应的腺苷受体不同于介导环磷酸腺苷积累的受体。
Naunyn Schmiedebergs Arch Pharmacol. 1984 Jul;326(4):294-301. doi: 10.1007/BF00501433.
6
Substance B: an endogenous brain factor that reverses presynaptic inhibition of acetylcholine release.物质B:一种可逆转乙酰胆碱释放的突触前抑制作用的内源性脑因子。
Proc Natl Acad Sci U S A. 1986 Oct;83(20):7979-83. doi: 10.1073/pnas.83.20.7979.