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High-affinity binding of [3H]muscimol to subcellular particles of a neurone-enriched culture of embryonic rat brain.

作者信息

DeFeudis F V, Ossola L, Schmitt G, Mandel P

出版信息

Neurosci Lett. 1979 Oct;14(2-3):195-9. doi: 10.1016/0304-3940(79)96147-0.

DOI:10.1016/0304-3940(79)96147-0
PMID:231232
Abstract

High-affinity, Na+-independent binding of [3H]muscimol (KB approximately equal to 1.6 x 10(-8) M; Bmax approximately equal to 0.14 nmol/g pellet) occurred to a frozen-thawed particulate fraction of 74-h-old neurone-enriched cultures prepared from the cerebra of 12-13-day-old rat embryos. This finding provides evidence that GABA-receptors exist on cultured neurones which contain only a few synaptic connections.

摘要

相似文献

1
High-affinity binding of [3H]muscimol to subcellular particles of a neurone-enriched culture of embryonic rat brain.
Neurosci Lett. 1979 Oct;14(2-3):195-9. doi: 10.1016/0304-3940(79)96147-0.
2
Binding of [3H]GABA and [3H]muscimol to subcellular particles of a neurone-enriched culture of mouse brain.[3H]γ-氨基丁酸（GABA）和[3H]蝇蕈醇与小鼠脑神经元富集培养物亚细胞颗粒的结合。
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Comparison of the "specific" binding of [3H]GABA and [3H]muscimol to a particulate fraction of rat brain.[3H]γ-氨基丁酸（GABA）和[3H]蝇蕈醇与大鼠脑微粒体部分的“特异性”结合比较
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Autoradiographic localization of 3H-GABA and 3H-muscimol binding in rat cerebellar cultures.大鼠小脑培养物中³H-γ-氨基丁酸（³H-GABA）和³H-蝇蕈醇结合的放射自显影定位
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Substrate specificity of [3H]muscimol binding to a particulate fraction of a neuron-enriched culture of embryonic rat brain.[3H]蝇蕈醇与胚胎大鼠脑神经元富集培养物的微粒体部分结合的底物特异性。
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Binsing studies with muscimol; relation ty synaptic gamma-aminobutyrate receptors.使用蝇蕈醇的研究；与突触γ-氨基丁酸受体的关系。
Neuroscience. 1980;5(4):675-88. doi: 10.1016/0306-4522(80)90165-7.
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Na+-independent binding of [3H]GABA and [3H]muscimol to subcellular particles of neural primary cultures and whole brain.[3H]γ-氨基丁酸（GABA）和[3H]蝇蕈醇与神经原代培养物和全脑亚细胞颗粒的钠离子非依赖性结合
J Neurochem. 1980 Jan;34(1):216-8. doi: 10.1111/j.1471-4159.1980.tb04644.x.

引用本文的文献

1
Binding of [3H]GABA and [3H]muscimol to subcellular particles of a neurone-enriched culture of mouse brain.[3H]γ-氨基丁酸（GABA）和[3H]蝇蕈醇与小鼠脑神经元富集培养物亚细胞颗粒的结合。
Experientia. 1980 May 15;36(5):597-9. doi: 10.1007/BF01965824.
2
Ligand-binding studies on GABA receptors--relation to physiology and behavior.γ-氨基丁酸（GABA）受体的配体结合研究——与生理学和行为的关系
Neurochem Res. 1984 Mar;9(3):405-12. doi: 10.1007/BF00963987.
3
Development of [3H]muscimol binding to subcellular particles of a culture of mouse brain.
[3H]蝇蕈醇与小鼠脑细胞培养物亚细胞颗粒结合的研究进展。
Neurochem Res. 1980 Dec;5(12):1279-90. doi: 10.1007/BF00964963.
4
Autoradiographic localization of 3H-GABA and 3H-muscimol binding in rat cerebellar cultures.大鼠小脑培养物中³H-γ-氨基丁酸（³H-GABA）和³H-蝇蕈醇结合的放射自显影定位
Exp Brain Res. 1980 Jan;38(2):241-3. doi: 10.1007/BF00236746.
5
GABA-agonists induce the formation of low-affinity GABA-receptors on cultured cerebellar granule cells via preexisting high affinity GABA receptors.γ-氨基丁酸（GABA）激动剂通过预先存在的高亲和力GABA受体诱导培养的小脑颗粒细胞上低亲和力GABA受体的形成。
Neurochem Res. 1986 Apr;11(4):599-606. doi: 10.1007/BF00965329.
6
Benzodiazepine receptor sites in the chick optic lobe: development and pharmacological characterization.鸡视叶中的苯二氮䓬受体位点：发育与药理学特性
Neurochem Res. 1991 Jan;16(1):57-62. doi: 10.1007/BF00965828.