Hosaka Ai, Takuma Hiroshi, Ohta Kiyoe, Tamaoka Akira
Department of Neurology, Faculty of Medicine, University of Tsukuba, and Clinical Research Center, National Hospital Organization, Utano National Hospital, Japan.
Intern Med. 2012;51(21):3077-9. doi: 10.2169/internalmedicine.51.8196. Epub 2012 Nov 1.
We herein report a case of ocular myasthenia gravis (MG) that was highly positive for anti-muscle-specific tyrosine kinase (MuSK) antibodies. The examined patient exhibited bilateral ptosis and lateral gaze palsy without any generalized symptoms and was diagnosed with ocular MG with anti-MuSK antibodies. She responded to treatment with prednisolone and immunosuppressants and experienced only ocular symptoms for four years and eight months after onset. Ocular MG with anti-MuSK antibodies lasting for a long term has rarely been described. Our findings suggest that it may be reasonable to test for the presence of anti-MuSK antibodies in patients who present with external ophthalmoplegia.
我们在此报告一例抗肌肉特异性酪氨酸激酶（MuSK）抗体高度阳性的眼肌型重症肌无力（MG）病例。该患者表现为双侧上睑下垂和外展神经麻痹，无任何全身症状，被诊断为抗MuSK抗体阳性的眼肌型MG。她对泼尼松龙和免疫抑制剂治疗有反应，发病后四年零八个月仅出现眼部症状。长期存在的抗MuSK抗体阳性的眼肌型MG鲜有报道。我们的研究结果表明，对于出现外眼肌麻痹的患者，检测抗MuSK抗体的存在可能是合理的。
