注射于大鼠黑质的大天尼酸和鹅膏蕈氨酸的相反转向效应。

Opposite turning effects of dainic and ibotenic acid injected in the rat substantia nigra.

作者信息

Porceddu M L, Piacente B, Morelli M, Di Chiara G

出版信息

Neurosci Lett. 1979 Dec;15(2-3):271-6. doi: 10.1016/0304-3940(79)96125-1.

Abstract

Unilateral intranigral administration of kainic and ibotenic acid, two putative stimulants of glutamatergic mechanisms, elicited turning behaviour starting from doses of 10 ng. While the turning produced by kainic acid was ipsilateral, that produced by ibotenic acid was contralateral to the injected side. Previous destruction of dopaminergic neurons on the side of the intranigral injection failed to reduce the turning behaviour. Peripheral treatment with picrotoxin did not reduce the turning in response to ibotenic acid. The results might suggest the existence of excitatory and inhibitory glutamate receptors which control nigral non-dopaminergic neurons mediating turning-behaviour.

摘要

向黑质单侧注射两种假定的谷氨酸能机制刺激剂——海藻酸和鹅膏蕈氨酸，从10纳克的剂量开始就引发了旋转行为。虽然海藻酸引起的旋转是同侧的，但鹅膏蕈氨酸引起的旋转是与注射侧对侧的。先前对黑质注射侧的多巴胺能神经元进行破坏并不能减少旋转行为。用印防己毒素进行外周处理并不能减少对鹅膏蕈氨酸的旋转反应。这些结果可能表明存在控制介导旋转行为的黑质非多巴胺能神经元的兴奋性和抑制性谷氨酸受体。