Kowalski T F, Guidotti S, Deffebach M, Kubilis P, Bishop M
Department of Anesthesiology, University of Washington, Seattle 98195.
J Appl Physiol (1985). 1990 Jan;68(1):125-9. doi: 10.1152/jappl.1990.68.1.125.
Obstruction of pulmonary arterial blood flow results in minimal biochemical and/or morphological changes in the involved lung. If the lung is reperfused, a syndrome of leukopenia and lung edema occurs. We used the radiolabeled microsphere technique to measure the response of the bronchial circulation in rabbits to acute pulmonary artery occlusion (PAO) and to pulmonary artery reperfusion. We found that the bronchial blood flow (Qbr) decreased from a base line of 0.37 +/- 0.10 to 0.09 +/- 0.04 (SE) ml.min-1.g dry lung-1 (P less than or equal to 0.05) after 4 h of PAO. In a separate group of animals, Qbr 24 h after PAO remained low (0.20 +/- 0.07 ml.min-1.g dry lung-1, P = 0.06). Qbr during PAO was inversely correlated with the wet-to-dry ratio after reperfusion (r = -0.68, P = 0.06). Qbr did not change during 4 h of reperfusion. We speculate that a critical level of Qbr may be necessary during PAO to prevent ischemia/reperfusion injury from occurring.
肺动脉血流受阻会导致受累肺组织出现轻微的生化和/或形态学改变。如果肺组织再灌注，会出现白细胞减少和肺水肿综合征。我们使用放射性微球技术来测量兔支气管循环对急性肺动脉闭塞（PAO）和肺动脉再灌注的反应。我们发现，PAO 4小时后，支气管血流量（Qbr）从基线值0.37±0.10降至0.09±0.04（SE）ml·min⁻¹·g干肺⁻¹（P≤0.05）。在另一组动物中，PAO后24小时Qbr仍较低（0.20±0.07 ml·min⁻¹·g干肺⁻¹，P = 0.06）。PAO期间的Qbr与再灌注后的湿干比呈负相关（r = -0.68，P = 0.06）。再灌注4小时期间Qbr未发生变化。我们推测，PAO期间可能需要一定临界水平的Qbr来防止缺血/再灌注损伤的发生。
