De Santis G, Williams J F, Dvir E, O'Brien B M, Hurley J V, Goldberg I
St. Vincent's Hospital, Melbourne, Victoria, Australia.
J Bone Joint Surg Br. 1990 Mar;72(2):309-11. doi: 10.1302/0301-620X.72B2.2312574.
A dose of 48 Gy of X-irradiation given over two to five weeks after grafting caused no significant delay in the rate of healing and only a small and statistically non-significant decrease in the torsional strength of the graft-bone junction of either vascularised or non-vascularised bone grafts of the tibiae of rabbits. Healing was faster and the union between the graft and adjacent bone developed torsional strength significantly more rapidly with vascularised than with non-vascularised grafts. These findings suggest that postoperative radiotherapy is unlikely to have a significantly deleterious effect on the healing of bone grafts used to repair defects produced by excision of malignant bone tumours.
在移植后两到五周给予48 Gy的X射线照射剂量，对愈合速度没有显著延迟，并且对兔胫骨的带血管或不带血管骨移植的移植骨与宿主骨交界处的抗扭强度仅有微小且无统计学意义的降低。带血管移植的愈合速度更快，移植骨与相邻骨之间的结合产生抗扭强度的速度明显比不带血管移植的更快。这些发现表明，术后放疗不太可能对用于修复恶性骨肿瘤切除所产生缺损的骨移植愈合产生显著有害影响。
