Luke D R, Beck J E, Vadiei K, Yousefpour M, LeMaistre C F, Yau J C
Department of Pharmaceutics, University of Houston, Texas.
J Clin Pharmacol. 1990 Feb;30(2):163-9. doi: 10.1002/j.1552-4604.1990.tb03457.x.
The metabolic effects of intravenous cyclosporine on lipids and lipoproteins were studied in 29 allogeneic bone marrow recipients compared with 13 autologous bone marrow patients not requiring cyclosporine therapy. Patients were monitored continuously from 5 days prior to 27 days following transplantation; cyclosporine treatment was initiated 4 days before transplantation. Fasting lipid and lipoprotein levels were measured in serial blood samples throughout the study period. Nutritional supplementation, conditioning regimens and concomitant medications were not significantly different between groups. Furthermore, no significant differences in age, weight, lipid, or lipoprotein levels were found at baseline between the patient groups. Cholesterol, triglyceride, low-density lipoprotein cholesterol, and very low-density lipoprotein cholesterol levels remained unchanged in autologous patients. As compared with baseline values, plasma total cholesterol increased by an average of 26 percent in allogeneic transplantation patients receiving cyclosporine. Similarly, the ratio of low-density lipoprotein to high-density lipoprotein cholesterol was fourfold greater in those patients treated with cyclosporine compared to the autologous group. We conclude that cyclosporine appears to elevate cholesterol levels. Neither acute graft vs host disease nor changes in hepatic function could explain the differences in plasma cholesterol levels between groups.
在29名同种异体骨髓移植受者中研究了静脉注射环孢素对脂质和脂蛋白的代谢影响，并与13名不需要环孢素治疗的自体骨髓移植患者进行了比较。从移植前5天到移植后27天对患者进行持续监测；环孢素治疗在移植前4天开始。在整个研究期间，对系列血样中的空腹脂质和脂蛋白水平进行测量。两组在营养补充、预处理方案和伴随用药方面无显著差异。此外，患者组之间在基线时的年龄、体重、脂质或脂蛋白水平无显著差异。自体骨髓移植患者的胆固醇、甘油三酯、低密度脂蛋白胆固醇和极低密度脂蛋白胆固醇水平保持不变。与基线值相比，接受环孢素治疗的同种异体移植患者的血浆总胆固醇平均升高了26%。同样，与自体骨髓移植组相比，接受环孢素治疗的患者中低密度脂蛋白与高密度脂蛋白胆固醇的比率高四倍。我们得出结论，环孢素似乎会升高胆固醇水平。急性移植物抗宿主病和肝功能变化均不能解释两组之间血浆胆固醇水平的差异。
