基质金属蛋白酶-3 多态性是否与心肌梗死患者的年龄相关性黄斑变性有关？
Does matrix metalloproteinase-3 polymorphism play a role in age-related macular degeneration in patients with myocardial infarction?
机构信息
Department of Ophthalmology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania.
出版信息
Medicina (Kaunas). 2012;48(8):404-9.
OBJECTIVE
The aim of our study was to determine if the genotype of the matrix metalloproteinase-3 (MMP-3) gene might carry the risk of age-related macular degeneration (ARMD) in patients with myocardial infarction.
MATERIAL AND METHODS
A total of 499 patients with an acute myocardial infarction or with a history of myocardial infarction were enrolled into the study. They were subdivided into 2 groups: 273 patients with ARMD and 226 patients without ARMD. The control group comprised 560 persons from a random sample of the Lithuanian population. DNA was analyzed using real-time polymerase chain reaction to genotype polymorphism 5A/6A at a position -1171 of the MMP-3 gene promoter.
RESULTS
Of the 499 patients with myocardial infarction, 47% had early-stage ARMD. The patients with ARMD were older than the patients in the group without ARMD (62.1±10.8 vs. 59.6±11.1, P<0.01). The analysis of MMP-3 gene polymorphism did not reveal any differences in the distribution of 5A/5A, 5A/6A, and 6A/6A genotypes between the ARMD group, non-ARMD group, and the control group (24.2%, 52.5%, and 23.3% in the ARMD group; 28.7%, 51.9%, and 19.4% in non-ARMD group; and 25.7%, 49.3% and 25.0%, in the control group, respectively).
CONCLUSIONS
MMP-3 gene polymorphism had no predominant effect on the development of ARMD in patients with myocardial infarction.
目的
本研究旨在确定基质金属蛋白酶-3（MMP-3）基因的基因型是否会增加心肌梗死后发生年龄相关性黄斑变性（ARMD）的风险。
材料与方法
共纳入 499 例急性心肌梗死或有心肌梗死病史的患者。他们分为 2 组：273 例 ARMD 患者和 226 例非 ARMD 患者。对照组由来自立陶宛人群随机样本的 560 人组成。使用实时聚合酶链反应分析 MMP-3 基因启动子-1171 位置 5A/6A 多态性的 DNA 基因型。
结果
在 499 例心肌梗死患者中，47%的患者患有早期 ARMD。与非 ARMD 组相比，ARMD 组患者年龄更大（62.1±10.8 岁比 59.6±11.1 岁，P<0.01）。MMP-3 基因多态性分析未发现 ARMD 组、非 ARMD 组和对照组之间 5A/5A、5A/6A 和 6A/6A 基因型的分布存在差异（ARMD 组分别为 24.2%、52.5%和 23.3%；非 ARMD 组分别为 28.7%、51.9%和 19.4%；对照组分别为 25.7%、49.3%和 25.0%）。
结论
MMP-3 基因多态性对心肌梗死后 ARMD 的发生没有主要影响。
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