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采用腹壁下深动脉穿支皮瓣进行乳房重建。

Breast reconstruction with deep inferior epigastric perforator flaps.

作者信息

Cubitt J, Barber Z, Khan A A, Tyler M

机构信息

Buckinghamshire Healthcare NHS Trust, UK, Stoke Mandeville Hospital, Mandeville Road, Aylesbury, HP21 8AL, UK.

出版信息

Ann R Coll Surg Engl. 2012 Nov;94(8):552-8. doi: 10.1308/003588412X13373405386457.

Abstract

INTRODUCTION

Approximately 45,000 women are diagnosed with breast cancer in the UK each year. The success of screening and the introduction of adjuvant therapies have meant that prognosis is improving and an increasing number of patients are seeking reconstruction following mastectomy. The purpose of this study was to evaluate the deep inferior epigastric perforator (DIEP) flap reconstructions performed in Stoke Mandeville Hospital and, through analysis of complications, detail the evolution of the current care pathway.

METHODS

A retrospective analysis was performed of all the DIEP flap reconstructions performed by the senior author (MT) between July 2003 and December 2010.

RESULTS

Overall, 159 flaps were performed on 141 patients (including 36 bilateral flaps). The average patient age was 49 years (range: 28-70 years) and 13% of flaps were risk reducing for BRCA1/2. Twenty-six per cent of patients suffered one or more complication post-operatively, including systemic complications (pulmonary embolism 2%) and flap specific complications (partial flap necrosis 9%, reanastomosis 3%, fat necrosis 9%). Seventy-four per cent had further elective operations including nipple reconstruction (72%), contralateral breast reduction (36%) and scar revision (21%).

CONCLUSIONS

DIEP flaps are a safe and reliable option for breast reconstructions. This series illustrates the significant leaning curve, with complications, operative time and ischaemic time reducing through the series and post-operative haemoglobin increasing. The complications experienced in this series of 159 flaps with no total flap loss provide the framework for the evolution of the current care pathway including pre-operative imaging, peri-operative deep vein thrombosis prophylaxis and analgesia.

摘要

引言

在英国,每年约有45,000名女性被诊断出患有乳腺癌。筛查的成功以及辅助治疗的引入意味着预后正在改善,越来越多的患者在乳房切除术后寻求乳房重建。本研究的目的是评估在斯托克曼德维尔医院进行的腹壁下深动脉穿支(DIEP)皮瓣乳房重建手术,并通过对并发症的分析,详细阐述当前护理路径的演变情况。

方法

对资深作者(MT)在2003年7月至2010年12月期间进行的所有DIEP皮瓣乳房重建手术进行回顾性分析。

结果

总体而言,对141例患者进行了159例皮瓣移植手术(包括36例双侧皮瓣移植)。患者的平均年龄为49岁(范围:28 - 70岁),13%的皮瓣移植是为降低BRCA1/2基因携带者患癌风险。26%的患者术后出现一种或多种并发症,包括全身并发症(肺栓塞2%)和皮瓣特异性并发症(部分皮瓣坏死9%、血管再吻合3%、脂肪坏死9%)。74%的患者接受了进一步的择期手术,包括乳头重建(72%)、对侧乳房缩小术(36%)和瘢痕修复(21%)。

结论

DIEP皮瓣是乳房重建的一种安全可靠的选择。本系列研究表明存在显著的学习曲线,随着手术例数增加,并发症、手术时间和缺血时间减少,术后血红蛋白水平升高。在这159例皮瓣移植手术中未出现皮瓣完全坏死的情况,所经历的并发症为当前护理路径的演变提供了框架,包括术前影像学检查、围手术期深静脉血栓预防和镇痛措施。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5c2/3954280/62d1b6289b5c/rcse9408-552-01.jpg

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