产后严重脑静脉窦血栓形成患者的局部溶栓治疗。
Local thrombolysis for patients of severe cerebral venous sinus thrombosis during puerperium.
机构信息
Department of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, 1 Jianshe Road, Zhengzhou 450052, China.
出版信息
Eur J Radiol. 2013 Jan;82(1):165-8. doi: 10.1016/j.ejrad.2012.07.019. Epub 2012 Nov 3.
OBJECTIVE
To explore and evaluate the efficacy of intrasinus thrombolysis (IST) in patients with cerebral venous sinus thrombosis (CVST) during postpartum period.
METHODS
11 patients during postpartum period with CVST who received IST during July 2007-November 2011 were included. Urokinase was infused into the sinuses via a microcatheter. Magnetic resonance venography (MRV) was performed to assess the recanalization of venous sinuses.
RESULTS
Before discharge, the intracranial pressure in 11 patients was under 200 mmH(2)O. MRV confirmed that venous sinus of 9 patients were smooth. The cortex venous and deep venous recovered to normal. Venous sinus of 2 patients recanalized partly, and cortex venous and deep venous had compensation. 9 patients had good outcome and 2 patients had only mild deficits.
CONCLUSION
Intrasinus thrombolysis is safe and effective in patients with severe cerebral venous sinus thrombosis during postpartum period.
目的
探讨和评估产后患者颅内静脉窦血栓形成（CVST）时鼻窦内溶栓（IST）的疗效。
方法
纳入 2007 年 7 月至 2011 年 11 月期间接受 IST 的 11 例产后 CVST 患者。通过微导管将尿激酶注入窦内。磁共振静脉造影（MRV）评估静脉窦再通情况。
结果
出院前，11 例患者颅内压均低于 200mmH2O。MRV 证实 9 例患者的静脉窦通畅。皮质静脉和深静脉恢复正常。2 例患者部分再通，皮质静脉和深静脉有代偿。9 例患者预后良好，2 例患者仅有轻度缺陷。
结论
产后严重颅内静脉窦血栓形成时，鼻窦内溶栓是安全有效的。
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