Department of Internal Medicine (Rheumatology), Yale School of Medicine, New Haven, CT 06520, United States.
Curr Opin Immunol. 2012 Dec;24(6):651-7. doi: 10.1016/j.coi.2012.10.004. Epub 2012 Nov 3.
Systemic lupus erythematosus (SLE, lupus) is characterized by a global loss of self-tolerance with activation of autoreactive T and B cells leading to production of pathogenic autoantibodies and tissue injury. Innate immune mechanisms are necessary for the aberrant adaptive immune responses in SLE. Recent advances in basic and clinical biology have shed new light on disease mechanisms in lupus, with this review discussing the recent studies that offer valuable insights into disease-specific therapeutic targets.
系统性红斑狼疮(SLE,狼疮)的特征是全身性的自身耐受丧失,导致自身反应性 T 和 B 细胞激活,从而产生致病性自身抗体和组织损伤。先天免疫机制对于 SLE 中异常的适应性免疫反应是必要的。基础和临床生物学的最新进展为狼疮的发病机制提供了新的认识,本文讨论了这些最新研究,为特定疾病的治疗靶点提供了有价值的见解。