Rao Hao-Han, Xie Wan-Chen, Guo Feng, Chen Huan-Wen
Department of Cardiothoracic Surgery, The First Affiliated Hospital of Chongqing Medical University, No.1, Youyi Road, Yuzhong District, Chongqing, 400016, China.
Department of Breast and Thyroid Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
Discov Oncol. 2025 Jul 7;16(1):1275. doi: 10.1007/s12672-025-03145-3.
Autoimmune diseases are closely linked with lung cancer (LC), forming a complex bidirectional relationship that poses significant challenges to treatment. A bibliometric analysis was conducted to investigate global research trends, key hotspots, and potential future directions in this field.
This study utilized bibliometric methods, analyzing 1161 publications from the Web of Science database spanning the years 1980 to 2024. Visualization and analysis were performed using tools such as VOSviewer, CiteSpace, and the bibliometrix R package.
The dataset encompassed research from 73 countries, 1860 organizations, and 6734 authors, published in 541 sources. The United States emerged as the leading contributor in terms of publication output, with the Mayo Clinic identified as the most productive institution. The Cureus Journal of Medical Science published the highest number of articles, whereas Chest garnered the most citations. Among individual researchers, Sasha Bernatsky stood out as the most prolific and frequently co-cited author. Keyword analysis revealed significant focus areas, including immune therapy-related adverse events, interstitial lung disease, comorbidities, diagnostic methods, and autoantibodies in paraneoplastic syndromes. Emerging research priorities center on understanding immune mechanisms, addressing comorbidities, and advancing diagnostic approaches.
This bibliometric study provides a comprehensive overview of research trends and gaps in the intersection of autoimmune diseases and LC. It highlights the importance of exploring immune therapy mechanisms, managing comorbidities, and optimizing diagnostic strategies as key areas for future investigation.
自身免疫性疾病与肺癌密切相关，形成了复杂的双向关系，给治疗带来了重大挑战。进行了一项文献计量分析，以研究该领域的全球研究趋势、关键热点和潜在的未来方向。
本研究采用文献计量方法，分析了来自科学网数据库的1161篇1980年至2024年期间的出版物。使用VOSviewer、CiteSpace和文献计量学R包等工具进行可视化和分析。
该数据集涵盖了来自73个国家、1860个组织和6734名作者的研究，发表在541种来源上。美国在出版物产出方面成为主要贡献者，梅奥诊所被确定为最具生产力的机构。《Cureus医学科学杂志》发表的文章数量最多，而《胸科》获得的引用最多。在个人研究人员中，萨沙·贝尔纳茨基是最多产且被频繁共同引用的作者。关键词分析揭示了重要的重点领域，包括免疫治疗相关不良事件、间质性肺疾病、合并症、诊断方法以及副肿瘤综合征中的自身抗体。新兴的研究重点集中在理解免疫机制、解决合并症和推进诊断方法上。
这项文献计量研究全面概述了自身免疫性疾病与肺癌交叉领域的研究趋势和差距。它强调了探索免疫治疗机制、管理合并症和优化诊断策略作为未来研究关键领域的重要性。
