表观遗传转录调控在BRCA1介导的肿瘤抑制中的作用。
The role of epigenetic transcriptional regulation in BRCA1-mediated tumor suppression.
作者信息
Chang Suhwan, Sharan Shyam K
机构信息
Dept. of Medicine, Graduate School, University of Ulsan College of Medicine, Asan Institute for Life Science, Songpa-gu, Seoul, Republic of Korea.
出版信息
Transcription. 2013 Jan-Feb;4(1):24-8. doi: 10.4161/trns.22600. Epub 2012 Nov 6.
Abstract
Mutation in BRCA1 accounts for half of all familial breast cancer cases. Recent studies have shown its role in the epigenetic regulation of an oncogenic microRNA, revealing a novel mode of tumor suppression that is independent of its well-established role in DNA repair and cell cycle regulation.
摘要
BRCA1基因的突变占所有家族性乳腺癌病例的一半。最近的研究表明，它在一种致癌性微小RNA的表观遗传调控中发挥作用，揭示了一种新的肿瘤抑制模式，这种模式独立于其在DNA修复和细胞周期调控中已确立的作用。
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