细胞周期带动转录周期：Cdc28/Cdk1是一种受细胞周期调控的转录周期蛋白依赖性激酶。
The cell cycle rallies the transcription cycle: Cdc28/Cdk1 is a cell cycle-regulated transcriptional CDK.
作者信息
Chymkowitch Pierre, Enserink Jorrit M
机构信息
Department of Molecular Biology, Institute of Medical Microbiology and Centre for Molecular Biology and Neuroscience, Oslo University Hospital, Oslo, Norway.
出版信息
Transcription. 2013 Jan-Feb;4(1):3-6. doi: 10.4161/trns.22456. Epub 2012 Nov 6.
Abstract
In the budding yeast Saccharomyces cerevisiae, the cyclin-dependent kinases (CDKs) Kin28, Bur1 and Ctk1 regulate basal transcription by phosphorylating the carboxyl-terminal domain (CTD) of RNA polymerase II. However, very little is known about the involvement of the cell cycle CDK Cdc28 in the transcription process. We have recently shown that, upon cell cycle entry, Cdc28 kinase activity boosts transcription of a subset of genes by directly stimulating the basal transcription machinery. Here, we discuss the biological significance of this finding and give our view of the kinase-dependent role of Cdc28 in regulation of RNA polymerase II.
摘要
在出芽酵母酿酒酵母中，细胞周期蛋白依赖性激酶（CDK）Kin28、Bur1和Ctk1通过磷酸化RNA聚合酶II的羧基末端结构域（CTD）来调节基础转录。然而，关于细胞周期CDK Cdc28在转录过程中的作用却知之甚少。我们最近发现，在细胞进入周期时，Cdc28激酶活性通过直接刺激基础转录机制来促进一组基因的转录。在此，我们讨论这一发现的生物学意义，并阐述我们对于Cdc28在RNA聚合酶II调节中依赖激酶的作用的看法。
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