Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong 510100, China.
Oxid Med Cell Longev. 2020 Mar 14;2020:2172740. doi: 10.1155/2020/2172740. eCollection 2020.
Nature is a vast source of bioactive molecules and has provided an active and efficient reservoir for drug discovery. Among natural compounds, one of the most promising is Schisandrin B (Sch B), isolated from Schisandra chinensis, which was documented to possess diversified pharmacokinetic propriety, among them antioxidant, anti-inflammation, cardioprotection, and neuroprotection. Due to its large biological properties, Sch B was recorded to be a potent cure for several diseases by targeting several signaling pathways. This review is aimed at emphasizing the recent data on the biological properties of Sch B among the molecular mechanism of this drug on tumoral, cardiac, and neural diseases. The data suggest that the antitumor activities of Sch B were mainly through apoptosis and cell cycle arrest at the diver's stage. It is reported that Sch B could be used as effective chemotherapy, neuroprotection, and cardioprotection since it possesses a spectrum of biological activities; however, further investigations on the mechanism of its action and preclinical trials are still mandatory to further validate the potential of this natural drug candidate.
大自然是生物活性分子的巨大源泉，为药物发现提供了一个活跃而高效的资源库。在天然化合物中，最有前途的一种是五味子素 B（Sch B），它从五味子中分离出来，具有多样化的药代动力学特性，包括抗氧化、抗炎、心脏保护和神经保护。由于其广泛的生物学特性，Sch B 被记录为通过靶向多种信号通路治疗多种疾病的有效药物。本综述旨在强调关于 Sch B 的生物学特性的最新数据，以及该药物在肿瘤、心脏和神经疾病中的分子机制。数据表明，Sch B 的抗肿瘤活性主要是通过凋亡和细胞周期阻滞在不同阶段。有报道称，Sch B 可作为有效的化疗、神经保护和心脏保护药物，因为它具有广泛的生物学活性；然而，仍然需要对其作用机制进行进一步的研究和临床前试验，以进一步验证这种天然药物候选物的潜力。
