Hashizume Keiji
Pain Center, Nara Medical University, Kashijyou-cho, Nara, Japan.
Brain Nerve. 2012 Nov;64(11):1315-22.
Pain is classified into physical and psychological pain. Physical pain is nociceptive, inflammatory, or neuropathic. Pain can be categorized into acute or chronic pain depending on the duration of pain and mechanism of onset. Acute pain heals as the underlying cause is resolved and includes naturally curable nociceptive and potentially curable neuropathic pain. Chronic pain is caused by incurable conditions or requires a long time to heal and is persistent: it includes chronic nociceptive pain, established neuropathic pain, and psychogenic pain. The therapeutic strategies for pain depend on the underlying pathological conditions: (1) For nociceptive pain, analgesics, narcotic analgesics, and nerve block are indicated. (2) For neuropathic pain, supplementary analgesics, but not analgesics, are indicated, and some narcotic analgesics are also effective: the recommended supplementary analgesics include calcium channel alpha-2-delta ligands, tricyclic antidepressants (TCAs), and serotonin-noradrenaline reuptake inhibitors (SNRIs). (3) For psychogenic pain, analgesics and nerve block are not indicated, except in the setting of a placebo effect: in paticular, narcotic analgesics should not be used. Psychological therapy, tranquilizer administration, cognitive behavior therapy, and patient education are indicated for this kind of pain.
疼痛分为生理性疼痛和心理性疼痛。生理性疼痛包括伤害性疼痛、炎症性疼痛或神经性疼痛。根据疼痛持续时间和发病机制,疼痛可分为急性疼痛或慢性疼痛。随着潜在病因的消除,急性疼痛会痊愈,包括自然可治愈的伤害性疼痛和潜在可治愈的神经性疼痛。慢性疼痛由无法治愈的病症引起或需要很长时间才能痊愈且持续存在:它包括慢性伤害性疼痛、已形成的神经性疼痛和心因性疼痛。疼痛的治疗策略取决于潜在的病理状况:(1)对于伤害性疼痛,可使用镇痛药、麻醉性镇痛药和神经阻滞。(2)对于神经性疼痛,应使用辅助镇痛药而非镇痛药,一些麻醉性镇痛药也有效:推荐的辅助镇痛药包括钙通道α2-δ配体、三环类抗抑郁药(TCA)和5-羟色胺-去甲肾上腺素再摄取抑制剂(SNRI)。(3)对于心因性疼痛,除了安慰剂效应外,不建议使用镇痛药和神经阻滞:特别是不应使用麻醉性镇痛药。对于这种疼痛,建议采用心理治疗、给予镇静剂、认知行为疗法和患者教育。