用多底物加合物探测肌醇 1-磷酸合酶。
Probing myo-inositol 1-phosphate synthase with multisubstrate adducts.
机构信息
College of Liberal Arts and Sciences, Biological Sciences, Wayne State University, 5047 Gullen Mall, Detroit, MI 48202, USA.
出版信息
Org Biomol Chem. 2012 Dec 28;10(48):9601-19. doi: 10.1039/c2ob26577j. Epub 2012 Nov 7.
Abstract
The synthesis of a series of carbohydrate-nucleotide hybrids, designed to be multisubstrate adducts mimicking myo-inositol 1-phosphate synthase first oxidative transition state, is reported. Their ability to inhibit the synthase has been assessed and results have been rationalised computationally to estimate their likely binding mode.
摘要
本文报道了一系列糖核苷酸杂合体的合成，这些杂合体旨在模拟肌醇-1-磷酸合酶的第一个氧化过渡态的多底物加合物。评估了它们抑制合酶的能力，并通过计算对结果进行了合理化，以估算它们可能的结合模式。
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