增殖标志物在乳腺病变中的作用。
Role of proliferative markers in breast lesions.
作者信息
Manna Asim Kumar, Pathak Swapan, Sarkar Diptendra Kumar
机构信息
Department of Pathology, IPGME&R, Kolkata, India.
出版信息
Indian J Surg. 2010 Feb;72(1):53-7. doi: 10.1007/s12262-010-0010-y. Epub 2010 Feb 5.
BACKGROUND
Carcinoma of breast is a leading cause of death in women throughout the world. Difficulty in diagnosis occurs in routine Hematoxylin and Eosin (H&E) stained sections to differentiate premalignant lesions like epitheliosis and malignant lesions like carcinoma in situ which may affect prognosis.
AIMS
Our study was done to assess the role of proliferative markers in this field.
MATERIALS AND METHODS
In this study, total 66 cases of different breast lesions were studied by H&E stained sections as well as proliferative markers like silver staining nucleolar organizer region (AgNOR) and proliferating cell nuclear antigen (PCNA).
RESULTS
Statistically significant differences found in expression of proliferative markers between most of them.
CONCLUSION
Study of proliferative markers help in the proper diagnosis of different breast lesions which lies in the grey zone on routine histopathology.
背景
乳腺癌是全球女性死亡的主要原因。在常规苏木精和伊红（H&E）染色切片中，难以区分上皮增生等癌前病变和原位癌等恶性病变，而这些病变可能影响预后。
目的
我们开展这项研究以评估增殖标志物在该领域的作用。
材料与方法
在本研究中，通过H&E染色切片以及增殖标志物如银染核仁组织区（AgNOR）和增殖细胞核抗原（PCNA）对总共66例不同乳腺病变进行了研究。
结果
大多数病变之间在增殖标志物表达上存在统计学显著差异。
结论
增殖标志物的研究有助于对常规组织病理学中处于灰色地带的不同乳腺病变进行准确诊断。
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