腹股沟疝修补术患者预防性抗生素的使用——一项临床研究
Prophylactic antibiotic usage in patients undergoing inguinal mesh hernioplasty - A clinical study.
作者信息
Thakur Loveleen, Upadhyay Shekhar, Peters Nitin J, Saini Navdeep, Deodhar Michael
机构信息
Department of Surgery, Dayanand Medical College and Hospital, Ludhiana, India.
出版信息
Indian J Surg. 2010 Jun;72(3):240-2. doi: 10.1007/s12262-010-0051-2. Epub 2010 Aug 26.
BACKGROUND
There is ambiguity about the use of antibiotic prophylaxis in inguinal mesh hernioplasty. We have tried to assess the efficacy of antibiotic prophylaxis in this procedure.
MATERIALS AND METHODS
A randomized double blind placebo controlled study was conducted which included 55 patients who underwent an inguinal mesh hernioplasty over a 2 year period. The patients were evaluated for the status of the suture line as well as the presence of wound infection.
RESULTS
Out of 55 patients 29 were randomized to the antibiotic arm and 26 to the placebo group. The groups were well matched for all variables studied excluding wound infections, which occurred at a rate of 10.34% (n = 3) in the antibiotic group and 15.38% (n = 4) in the placebo arm, (p > 0.01).
CONCLUSION
This study did not document any statistically significant difference observed between those who received antibiotics and those receiving placebo in terms of any of the prognostic end points evaluated for Lichtenstein mesh hernioplasty.
背景
腹股沟疝修补术中抗生素预防性使用存在争议。我们试图评估该手术中抗生素预防的效果。
材料与方法
进行了一项随机双盲安慰剂对照研究，纳入了55例在2年期间接受腹股沟疝修补术的患者。对患者的缝线情况以及伤口感染情况进行评估。
结果
55例患者中，29例随机分配至抗生素组，26例分配至安慰剂组。除伤口感染外，两组在所有研究变量上匹配良好，抗生素组伤口感染发生率为10.34%（n = 3），安慰剂组为15.38%（n = 4），（p > 0.01）。
结论
本研究未发现接受抗生素治疗的患者与接受安慰剂治疗的患者在评估Lichtenstein疝修补术的任何预后终点方面存在任何统计学上的显著差异。
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