如何研究正电子发射断层显像/计算机断层扫描（PET/CT）监测癌症治疗的最佳时机。
How to study optimal timing of PET/CT for monitoring of cancer treatment.
作者信息
Vach Werner, Høilund-Carlsen Poul Flemming, Fischer Barbara Malene, Gerke Oke, Weber Wolfgang
机构信息
Clinical Epidemiology, Institute of Medical Biometry and Medical Informatics, University Medical Center Freiburg Stefan-Meier-Str. 26, D-79104 Freiburg, Germany.
出版信息
Am J Nucl Med Mol Imaging. 2011;1(1):54-62. Epub 2011 Jul 20.
PURPOSE
The use of PET/CT for monitoring treatment response in cancer patients after chemo- or radiotherapy is a very promising approach to optimize cancer treatment. However, the timing of the PET/CT-based evaluation of reduction in viable tumor tissue is a crucial question. We investigated how to plan and analyze studies to optimize this timing.
METHODS
General considerations about studying the optimal timing are given and four fundamental steps are illustrated using data from a published study.
RESULTS
The optimal timing should be examined by optimizing the schedule with respect to predicting the overall individual time course we can observe in the case of dense measurements. The optimal timing needs not to and should not be studied by optimizing the association with the prognosis of the patient.
CONCLUSIONS
The optimal timing should be examined in specific 'schedule optimizing studies'. These should be clearly distinguished from studies evaluating the prognostic value of a reduction in viable tumor tissue.
目的
使用正电子发射断层扫描/计算机断层扫描（PET/CT）监测癌症患者在化疗或放疗后的治疗反应，是优化癌症治疗的一种非常有前景的方法。然而，基于PET/CT评估存活肿瘤组织减少情况的时机是一个关键问题。我们研究了如何规划和分析研究以优化这一时机。
方法
给出了关于研究最佳时机的一般考虑因素，并使用一项已发表研究的数据说明了四个基本步骤。
结果
应通过优化时间表来检查最佳时机，以便预测在密集测量情况下我们能够观察到的个体总体时间进程。最佳时机不需要也不应该通过优化与患者预后的关联来研究。
结论
应在特定的“时间表优化研究”中检查最佳时机。这些研究应与评估存活肿瘤组织减少的预后价值的研究明确区分开来。
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