Department of Experimental Medicine, Section of Pharmacology Leonardo Donatelli, Second University of Naples, Naples, Italy.
Clin Toxicol (Phila). 2012 Dec;50(10):902-10. doi: 10.3109/15563650.2012.740484. Epub 2012 Nov 8.
To the average consumer, "cosmetics" are not considered to cause damage to human health under normal conditions of use. Thus, cosmetic "safety" does not require any particular attention to the possibility that cosmetics may result in a toxic exposure, especially for children. Poison Control Centres (PCCs) provide specialized and rapid information for consumers and health professionals to ensure management of events related to the exposures to different agents, including Cosmetics. Poison Control Centres also represent a unique source of information to investigate the frequency and type of exposures to cosmetic and the related risks.
An analysis of cases concerning human exposures to cosmetics collected from 2005 to 2010 by the PCC at the Ospedale Niguarda Ca' Granda (Milan, Italy) was performed.
During this period, 11 322 human exposure cases related to cosmetics were collected accounting for 4.5% of the total human clinical cases. Almost, all the requests for assistance came from consumers (53%) and hospitals (40%). The most frequently reported site of exposure was the consumer's own residence (94%). The exposures mainly involved children younger than 4 years (77%). No difference in gender distribution was observed (female 49%, male 51%). Almost, all of the exposures were unintentional (94%). Intentional exposures, mainly related to suicide attempts and accounted for 6% of cases involving persons aged more than 12 years. Personal hygiene products (30%), perfumes and hair care products (excluding hair dyes) (both 13%) were the most frequently involved categories. Symptoms were present only in 26% of the exposures and were mostly gastrointestinal (46%). Most of the cases were managed at home (43%) whereas hospital intervention was required in 38%.
Since the exposure frequency seems more likely to reflect product availability and accessibility to ingestors, our results call for closer attention to this type of hazard, especially for children younger than 4 years of age.
对于普通消费者而言,化妆品在正常使用条件下不会被认为会对人体健康造成损害。因此,化妆品的“安全性”无需特别关注化妆品可能导致毒性暴露的可能性,尤其是对儿童而言。中毒控制中心(PCC)为消费者和医疗专业人员提供专业和快速的信息,以确保对不同药剂(包括化妆品)暴露事件进行管理。中毒控制中心也是调查与化妆品暴露相关的频率和类型以及相关风险的独特信息来源。
对米兰尼瓜尔达医院(意大利米兰)中毒控制中心在 2005 年至 2010 年期间收集的有关人类接触化妆品的病例进行分析。
在此期间,共收集到 11322 例与化妆品相关的人类暴露病例,占总人类临床病例的 4.5%。几乎所有寻求帮助的请求都来自消费者(53%)和医院(40%)。报告暴露部位最频繁的是消费者自己的住所(94%)。暴露主要涉及 4 岁以下儿童(77%)。性别分布无差异(女性占 49%,男性占 51%)。几乎所有暴露都是无意的(94%)。故意暴露主要与自杀企图有关,占涉及 12 岁以上人群的病例的 6%。个人卫生用品(30%)、香水和头发护理产品(不包括染发剂)(均占 13%)是最常涉及的类别。仅 26%的暴露出现症状,且大多为胃肠道症状(46%)。大多数病例在家庭中得到处理(43%),而 38%需要住院治疗。
由于暴露频率似乎更有可能反映产品的可获得性和摄入者的可及性,因此我们的结果呼吁对此类危害给予更多关注,尤其是对 4 岁以下儿童。