维生素D受体BsmI基因多态性与骨质疏松症风险：来自26项研究的荟萃分析

Vitamin D receptor BsmI polymorphism and osteoporosis risk: a meta-analysis from 26 studies.

作者信息

Jia Fu, Sun Rui-Fen, Li Qun-Hui, Wang Da-Xing, Zhao Feng, Li Jun-Min, Pu Qi, Zhang Zhong-Zi, Jin Yan, Liu Bai-Lian, Xiong Ying

机构信息

Department of Orthopedics, Kunming Medical University, National Clinical Key Specialty, Yanan Hospital, Kunming, People's Republic of China.

出版信息

Genet Test Mol Biomarkers. 2013 Jan;17(1):30-4. doi: 10.1089/gtmb.2012.0267. Epub 2012 Nov 7.

DOI:10.1089/gtmb.2012.0267

PMID:23134477

Abstract

OBJECTIVE

Growing evidence has shown that vitamin D deficiency can cause lower bone mineral density (BMD) and an increased risk of osteoporosis. Vitamin D receptor (VDR) BsmI polymorphism (rs1544410) can affect BMD variation and circulating osteocalcin levels. To date, a wide range of epidemiological studies have been carried out to evaluate the association between VDR BsmI polymorphism and susceptibility to osteoporosis. Conflicting results, however, were obtained. The aim of this study was to evaluate the effect of VDR BsmI polymorphism on osteoporosis risk using a meta-analysis.

METHODS

Twenty-six publications were identified by searching PubMed and Embase databases. The association between VDR BsmI polymorphism and osteoporosis was estimated by calculating pooled odds ratios (ORs) with corresponding 95% confidence intervals (CIs).

RESULTS

The bb genotype was associated with a significantly decreased risk of osteoporosis in overall comparison (bb vs. BB: OR=0.61, 95% CI, 0.40-0.92; bb vs. BB/Bb: OR=0.70, 95% CI, 0.52-0.95, respectively). Subgroup analyses showed that the bb genotype had a decreased risk of developing osteoporosis in postmenopausal women (bb vs. BB/Bb: OR=0.68, 95% CI, 0.46-0.98) and Africans (Bb/bb vs. BB: OR=0.18, 95% CI, 0.09-0.37).

CONCLUSION

The VDR BsmI polymorphism may have a protective role against the development of osteoporosis.

摘要

目的

越来越多的证据表明，维生素D缺乏会导致骨密度降低以及骨质疏松风险增加。维生素D受体（VDR）BsmI多态性（rs1544410）会影响骨密度变化和循环骨钙素水平。迄今为止，已开展了大量流行病学研究来评估VDR BsmI多态性与骨质疏松易感性之间的关联。然而，研究结果相互矛盾。本研究的目的是通过荟萃分析评估VDR BsmI多态性对骨质疏松风险的影响。

方法

通过检索PubMed和Embase数据库确定了26篇文献。通过计算合并比值比（OR）及相应的95%置信区间（CI）来评估VDR BsmI多态性与骨质疏松之间的关联。

结果

在总体比较中，bb基因型与骨质疏松风险显著降低相关（bb与BB比较：OR = 0.61，95%CI为0.40 - 0.92；bb与BB/Bb比较：OR分别为0.70，95%CI为0.52 - 0.95）。亚组分析表明，bb基因型在绝经后女性（bb与BB/Bb比较：OR = 0.68，95%CI为0.46 - 0.98）和非洲人群（Bb/bb与BB比较：OR = 0.18，95%CI为0.09 - 0.37）中发生骨质疏松的风险降低。