Hughes N R, Newland R C
University of Sydney Department of Surgery, Repatriation General Hospital, Concord, N.S.W., Australia.
J Pathol. 1990 Jan;160(1):41-50. doi: 10.1002/path.1711600110.
The histology and immunohistochemistry of 896 polyps and other focal epithelial abnormalities detected macroscopically in 86 surgical resections from patients with colorectal adenocarcinoma and benign bowel disorders were studied. The lesions identified included 177 adenomas, 387 hyperplastic (metaplastic) polyps, and 202 non-neoplastic polyps designated 'focal cryptal hyperplasia'. Numbers of both neoplastic and non-neoplastic polyps were significantly increased in resections for carcinoma, with 72 per cent of all polyps in right and 10 per cent in left hemicolectomy specimens being neoplastic. Thirty per cent of adenomas were less than 2 mm in diameter and 6 per cent larger than 10 mm. Observations on polyp size, number, distribution, histological appearance, and antigenic composition suggested that focal cryptal hyperplasia evolves into the hyperplastic polyp. In doing so, there is loss of expression of a tissue specific antigen. Hyperplastic polyps were significantly larger in colons with adenoma than in those without.
对86例结直肠癌和良性肠道疾病患者手术切除标本中肉眼检测到的896个息肉及其他局灶性上皮异常进行了组织学和免疫组织化学研究。所识别的病变包括177个腺瘤、387个增生性（化生）息肉以及202个被称为“局灶性隐窝增生”的非肿瘤性息肉。在癌切除标本中，肿瘤性和非肿瘤性息肉的数量均显著增加，右半结肠切除标本中所有息肉的72%为肿瘤性，左半结肠切除标本中为10%。30%的腺瘤直径小于2mm，6%大于10mm。关于息肉大小、数量、分布、组织学表现和抗原组成的观察表明，局灶性隐窝增生演变为增生性息肉。在此过程中，一种组织特异性抗原的表达丧失。有腺瘤的结肠中增生性息肉明显大于无腺瘤的结肠。
