Department of Pathomorphology and Oncological Cytology, Wroclaw Medical University, ul. Borowska 213, 50-556 Wroclaw, Poland.
Arch Gynecol Obstet. 2013 Mar;287(3):563-70. doi: 10.1007/s00404-012-2589-7. Epub 2012 Nov 8.
To determine the prognostic value of the immunohistochemical evaluation of the multidrug resistance-associated protein 2 (MRP2) expression, together with its subcellular localization in primary fallopian tube carcinomas (PFTCs).
The immunohistochemical analysis was performed using samples originating from 70 patients with PFTCs.
(1) We documented that MRP2 can be localized in the plasma membrane (MRP2c), as well as in the nuclear envelope (MRP2n) of the PFTC cells. (2) Patients with more advanced stage, with progression of the disease and patients who died, showed significantly higher expression of the MRP2n. (3) Univariate and multivariate analyses showed that MRP2n is an unfavorable prognostic factor in PFTCs. (4) The analysis of the classic clinicopathological data revealed that only the FIGO stage had prognostic value, both in the univariate, as well as in multivariate analysis.
(1) This study suggests that MRP2n is a new disadvantageous prognostic factor in PFTCs and (2) that expression in nuclear envelope can be associated with lower differentiation of cancer cells and their resistance to the cisplatin. (3) We have also confirmed independent prognostic value of FIGO stage in PFTCs.
确定多药耐药相关蛋白 2（MRP2）表达的免疫组织化学评估及其在原发性输卵管癌（PFTC）中的亚细胞定位的预后价值。
使用源自 70 例 PFTC 患者的样本进行免疫组织化学分析。
（1）我们证明 MRP2 可以定位于 PFTC 细胞的质膜（MRP2c）以及核膜（MRP2n）。（2）疾病进展和死亡的晚期患者、疾病进展的患者，MRP2n 的表达显著更高。（3）单因素和多因素分析表明，MRP2n 是 PFTC 的不利预后因素。（4）对经典临床病理数据的分析表明，只有 FIGO 分期在单因素和多因素分析中均具有预后价值。
（1）本研究表明，MRP2n 是 PFTC 的新的不利预后因素，（2）核膜表达可能与癌细胞分化程度较低以及对顺铂的耐药性有关，（3）我们还证实了 FIGO 分期在 PFTC 中的独立预后价值。
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