镍催化二苯基氧化膦与芳基氯的 C-P 交叉偶联。

Nickel-catalyzed C-P cross-coupling of diphenylphosphine oxide with aryl chlorides.

机构信息

State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, PR China.

出版信息

Org Biomol Chem. 2012 Dec 28;10(48):9627-33. doi: 10.1039/c2ob26874d. Epub 2012 Nov 7.

Abstract

A novel protocol for the preparation of various diarylphosphine oxide compounds via a Ni-catalyzed cross-coupling of aryl chlorides with R(2)P(O)H has been developed. Notably, this process exhibits the following very attractive features: (i) the process is simpler and operates under mild reaction conditions; (ii) the process is generally cheaper in part because the more accessible aryl chloride is used to form the C-P bond; (iii) the process avoids the need for simultaneous preparation and use of Ar(2)P(O)M.

摘要

一种通过 Ni 催化芳基氯与 R(2)P(O)H 的交叉偶联制备各种二芳基氧化膦化合物的新方法已经开发出来。值得注意的是，该过程具有以下非常吸引人的特点：(i) 该过程更简单，在温和的反应条件下进行；(ii) 该过程通常更便宜，部分原因是更易获得的芳基氯用于形成 C-P 键；(iii) 该过程避免了同时制备和使用 Ar(2)P(O)M 的需要。